Protein Alignment Hsc70-3 and hsp-110

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_498868.1
• Gene: hsp-110 / 176195
• WormBaseID: WBGene00016250
• Length: 776
• Species: Caenorhabditis elegans
• Alignment Length: 684
• Identity: 196/684 - (28%)
• Similarity: 340/684 - (49%)
• Gaps: 78/684 - (11%)

  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            :|:|.|:|.....:||.:.|.:|:|.||.....||:.|:| ...:|.:|.||:..:|||.:|||.
 Worm     2 SVLGFDIGNLNCYIGVARQGGIEVITNDYSLHATPACVSF-GPKDRSMGVAARQAVTTNIKNTVI 65

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            :.|.||||::||...|..|.|.|.|||: .|....:.|........|.||::.|.:|.|::...|
 Worm    66 NFKHLIGRKFSDPVAQRFIPFIPCKVVKLPNDDIGVQVSYLGEPHTFTPEQVLAALLTKLRTIVE 130

  Fly   159 AYLG--KKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKE------ 215
            :.|.  |||:..|:.||:||.|.||:|...|...|||..:||:||.||.|:|||:.|::
 Worm   131 SQLSDVKKVSDCVLAVPSYFTDVQRRAVLSAIQYAGLNSLRIVNETTAIALAYGIYKQDLPEEDA 195

  Fly   216 GEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRK 280
            ..:||:..|:|..:...||:..:.|..::|.|:.|...||..||..:.:||.|.:|.|.|.|...
 Worm   196 KSRNVVFLDIGHSSTQASLVAFNRGKLQMVNTSYDLESGGIWFDALIREHFRKEFKTKYGIDAAT 260

  Fly   281 DNRAVQKLRREVEKAKRALSGSH-QVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQK 344
            ..|...:|..|.|:.|:.:|.:. .:.:.||.|.|..|.:..:.|.:||:|...:|..    :::
 Worm   261 SPRPWLRLLDECERVKKQMSANQTPIPLNIECFMEDKDVTGKMQRQEFEDLAAPIFNR----IKQ 321

  Fly   345 VL-----EDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGV 404
            ||     :...:..:::.||.:||||:|||.::::|||.| ||||...:|.|||||.|||:|..:
 Worm   322 VLINLFADGVSIKPEEIDEIEIVGGSSRIPMIREIVKDLF-GKEPKTTMNQDEAVARGAAMQCAI 385

  Fly   405 LSGEQDTDAIVLLDVNPLTMGIE-----TVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQ 464
            ||.........:.|..|..:.:.     ..||......||:.|..:|...:..:...|     ::
 Worm   386 LSPTFRVREFAIKDTQPYRIRLSWNSTGENGGENDVFSPRDEVPFSKLVSLLRSGPFN-----VE 445

  Fly   465 VYEGERPMTKDNHL-LGKFDLTGI-PPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIV-- 525
            .:..:..:...|.: :|.:.:.|. |.|..|..:::|...::.:||..:::   .|..:.:||
 Worm   446 AHYAQPNVVPHNQVHIGSWKVNGARPGADGGNQKVKVKVRVNPDGIFTIAS---ATMYEPRIVEE 507

  Fly   526 -------ITND--------------QNRLTPEDID-----RMIRDAEKF-------ADEDKKLKE 557
                   :..|              :.:|.|.|::     .:..|.:||       .:.|.:.|.
 Worm   508 VPAEAMEVDGDAKTEAPAEPLEPVKKTKLVPVDLEVIESIPVSYDVQKFHNLELQMQESDAREKA 572

  Fly   558 RVESRNELESYAYSLKNQIGDK--DKLGAKLSDDEKNKLESAIDESIKWL-EQNPDADPEEYKKQ 619
            :.:::|.||.|.|.:::::.|:  :.:....:|:.::.|.|..|    || ::..||:.:.|:|:
 Worm   573 KADAKNSLEEYVYEMRDKVSDQYAEFITPAAADEFRSVLTSTED----WLYDEGEDAERDVYEKR 633

  Fly   620 KKDLEAIVQPVIAKLYQGAGGAPPPEGGDDADLK 653
            ..:|:|:..||:.:..:.....|..:..|.:.::
 Worm   634 LSELKAVGTPVVERYRESETRKPAFDSFDQSIMR 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	193/670 (29%)
hsp-110	NP_498868.1	HSP70	3..650	CDD:394970	194/664 (29%)