Protein Alignment Hsc70-3 and T24H7.2

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_495249.1
• Gene: T24H7.2 / 174033
• WormBaseID: WBGene00020781
• Length: 925
• Species: Caenorhabditis elegans
• Alignment Length: 781
• Identity: 192/781 - (24%)
• Similarity: 329/781 - (42%)
• Gaps: 176/781 - (22%)

  Fly     5 ILLAVVAFVGLSLGEEKKEKDKELGTVIGIDLGTTYSCVGVYKNG-RVEIIANDQGNRITPSYVA 68
            :||.::      ||......|.:|..:. |||||.:..:|:.|.| .::|..|.:..|.||: |.
 Worm     7 VLLVIL------LGCLFATSDGQLAAMT-IDLGTQFLKIGIVKPGIPMDIALNTESRRKTPN-VV 63

  Fly    69 FTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDI--------KFFPFKVVEKNS 125
            ...||.|...|||.......|.........|:|:     :.||..        .||......||:
 Worm    64 MIQDGHRTFADAAIGMQVRYPHLVHGQLNDLVGK-----STQHPSFELFKRRNTFFEVDDAPKNA 123

  Fly   126 KPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYL-GKKVTHAVVTVPAYFNDAQRQATKDAGV 189
            .   |::...|.:.:..|.::||:|...|:..|.|. ..::...|:|||.||..|:|.|.:.|..
 Worm   124 S---SINFKLGGESYTVEALTAMILANAKKFTEEYAQAAEIKDVVITVPVYFTPAERLAVERAAQ 185

  Fly   190 IAGLQVMRIINEPTAAAIAYGLDKKE--GEK--NVLVFDLGGGTFDVSLLTI--------DNGVF 242
            :|||.|:::||:.||||:::|:.:::  |||  .::|:|:|......:::..        .....
 Worm   186 MAGLTVLQLINDGTAAALSHGIFRRKEIGEKPQRLMVYDMGAAKTTATIVEFKLVKEKYEKQPKM 250

  Fly   243 EVVATNGDTHLGGEDFDQRVMDHFIKLYKK--KKGKDIRKDNRAVQKLRREVEKAKRALSGSHQV 305
            .|:....|..|||.:...|:.||.|::::|  |....:..:.||:.|..:|.|:.|:.||.:.:.
 Worm   251 TVLGVGFDRTLGGIEMTNRLRDHLIEMFEKNYKPKTKVNTNRRAMTKFSKEAERLKQVLSANAEH 315

  Fly   306 RIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPK 370
            ..:|||..|..|....:||..|..|..|:.....:|:::.|..|.:...|:.:.||:|..||:||
 Worm   316 FAQIESAHEDIDAKLKVTREDFNHLISDMESRFGEPIEQALRMAQIPIDDIDQFVLMGAGTRVPK 380

  Fly   371 VQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSG-------EQDTDAIVLLDVNPLTM---- 424
            ||::|:...|.||..:.:|.|||||.||..||..||.       ..:...|..::|:.::.
 Worm   381 VQEIVQKTIGTKEIGKFLNTDEAVAMGALFQAAHLSKGFKVKPFNIEEKVIFPVEVHFVSKIRDE 445

  Fly   425 GIETVGG---VMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTK----------DN 476
            ..|.:.|   |:..|...|:|.||....:..|:..:..:|.:: |......||          ||
 Worm   446 KTEEITGEKNVVKTLFAANSVYPTHPKTISLTSYSDDFSVALK-YGKIESFTKQQVQEIGSLLDN 509

  Fly   477 HLLGKFDLTGIPPAPRG-------IPQIEVSFEIDANGILQV----------------------- 511
              |...:::|:..|.:.       ...::|||.:||:||::|
 Worm   510 --LVDVEISGLSEALKNRSSEESEFKGVKVSFIVDASGIVRVRRAEALFEPKSGLVGSIASTISG 572

  Fly   512 -------------------SAEDKGTGNKEKIVI---------------TNDQNRLTPE------ 536
                               |.|:| |..||.:.:               |::::..|.|
 Worm   573 LFSSKTEEGEPTTDDSTPQSTEEK-TEEKESVKVEDSTPEPEPETPVNSTSEESPKTNETEKNAS 636

  Fly   537 -----------------------------------DIDRMIRDAEKFADEDKKLKERVESRNELE 566
                                               |:....|..|.||::::...||....||||
 Worm   637 SGNATEVKEKKKELPSIVRLRITNKYPSAFVPNKYDVQEEKRRMEAFAEKERLASERAAVENELE 701

  Fly   567 SYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQN--PDADPEEYKKQKKDLEAIVQP 629
            |:.:.. :|..::.:....::|:||.|||.::.....|||.:  .|...:::.....:|:.:|:.
 Worm   702 SFNFEC-SQYLEETEFTDYMADEEKTKLEDSVKRIRAWLEDDVTKDTPTKDFTDNLLELKNVVRS 765

  Fly   630 V 630
            |
 Worm   766 V 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	186/754 (25%)
T24H7.2	NP_495249.1	ASKHA_NBD_HSP70_HYOU1	25..413	CDD:466828	120/397 (30%)