DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-3 and Hspa4

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_032326.3	Gene:	Hspa4 / 15525	MGIID:	1342292	Length:	842	Species:	Mus musculus

Alignment Length:	708	Identity:	204/708 - (28%)
Similarity:	345/708 - (48%)	Gaps:	129/708 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            :|:|||||.....|.|.:.|.:|.|||:..:|.||:.|:| ....|.||.|||:|:.:|.:|||.
Mouse     2 SVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSF-GPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQ------GAKV--------FAPEEI 145
            ..||..||.:||          ||...||:   :::.|..|      |.||        |..|::
Mouse    66 GFKRFHGRAFSD----------PFVEAEKS---NLAYDIVQLPTGLTGIKVTYMEEERNFTTEQV 117

  Fly   146 SAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYG 210
            :||:|.|:|||||:.|.|.|...||:||:::.||:|::..||..||||..:|::||.||.|:|||
Mouse   118 TAMLLSKLKETAESVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYG 182

  Fly   211 LDK------KEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKL 269
            :.|      :|..:||:..|:|...:.||:...:.|..:|:||..||.|||..||:.:::||.:.
Mouse   183 IYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNKGKLKVLATAFDTTLGGRKFDEVLVNHFCEE 247

  Fly   270 YKKKKGKDIRKDNRAVQKLRREVEKAKRALS-GSHQVRIEIESFFEGDDFSETLTRAKFEELNLD 333
            :.||...||:...||:.:|.:|.||.|:.:| .:..:.:.||.|....|.|.|:.|.||.|:..|
Mouse   248 FGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDD 312

  Fly   334 LFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGA 398
            |......|::.|||.:.:.|:|::.:.:|||:||||.|::.:..|| |||.|..:|.||||..|.
Mouse   313 LLARVEPPLRSVLEQSKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGC 376

  Fly   399 AVQAGVLSGEQDTDAIVLLDVNPLTMGIE-----TVGGVMTKLIPRNTVIPTKKSQVFSTASDNQ 458
            |:|..:||.........:.||.|..:.:.     ..|....::.|:|...|..|...|.    .:
Mouse   377 ALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGLSDCEVFPKNHAAPFSKVLTFY----RK 437

  Fly   459 HTVTIQV-YEGERPMTKDNHLLGKFDLTGIPPAPRG-IPQIEVSFEIDANGILQVSA-------- 513
            ...|::. |...:.:...:..:.:|.:..:.|...| ..:::|...::.:||..||:
Mouse   438 EPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHK 502

  Fly   514 ---------EDKGTGNKEKIVI---------------TNDQNRLTPED----------------- 537
                     .|:....:||:.:               |..:|:...|:
Mouse   503 SEESEEPMETDQNAKEEEKMQVDQEEPHTEEQQQQPQTPAENKAESEEMETSQAGSKDKKTDQPP 567

  Fly   538 -----------------------IDRMI-----RDAEKFADEDKKLKERVESRNELESYAYSLKN 574
                                   :||.:     .:..|...:||..|||.:::|.:|.|.|.:::
Mouse   568 QAKKAKVKTSTVDLPIESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRD 632

  Fly   575 QI-GDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEE-YKKQKKDLEAIVQPV 630
            :: |:.:|.   :|:|::|.....::::..||.::.:..|:: |..:..:|:::.||:
Mouse   633 KLSGEYEKF---VSEDDRNTFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKSLGQPI 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	153/393 (39%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	203/706 (29%)
Hspa4	NP_032326.3	HSPA4_NBD	2..384	CDD:212687	153/396 (39%)
		HSP70	3..609	CDD:278441	183/624 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..577		6/76 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900