Protein Alignment Hsc70-3 and Hsph1

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: XP_006504979.1
• Gene: Hsph1 / 15505
• MGIID: 105053
• Length: 877
• Species: Mus musculus
• Alignment Length: 830
• Identity: 194/830 - (23%)
• Similarity: 322/830 - (38%)
• Gaps: 276/830 - (33%)

  Fly    65 SYVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPH 128
            |.::| ....|.||.|||||..|:..|||...||..||.::|..:|.:.:...:.:|. ||....
Mouse    56 SVISF-GSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVG 119

  Fly   129 ISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGL 193
            |.|........|:.|:|:||:|.|:|||||..|.|.||..|::||::|.||:|::..||..|.||
Mouse   120 IKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGL 184

  Fly   194 QVMRIINEPTAAAIAYGLDKK-----EGEKNVLVF-DLGGGTFDVSLLTIDNGVFEVVATNGDTH 252
            ..:|::|:.||.|:.||:.|:     |.:..|:|| |:|..:|.||....:.|..:|:.|..|..
Mouse   185 NCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPF 249

  Fly   253 LGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRAL-SGSHQVRIEIESFFEGD 316
            |||::||:::::||...:|.|...|.:...||:.:|.:|.||.|:.: |.|..:.:.||.|....
Mouse   250 LGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDK 314

  Fly   317 DFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGG 381
            |.|..:.|::||||..:|.:....|:..::....:..:||..|.:|||:||||.|::.:..|| |
Mouse   315 DVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKFF-G 378

  Fly   382 KEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGI-------ETVGGVMTKLIPR 439
            |:.|..:|.|||||.|.|:|..:||.........:.|..|..:.:       ||.|  :.::..|
Mouse   379 KDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEG--VHEVFSR 441

  Fly   440 NTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIP--------- 495
            |...|..|...|...                         |.|:|......|:|:|
Mouse   442 NHAAPFSKVLTFLRR-------------------------GPFELEAFYSDPQGVPYPEAKIGRF 481

  Fly   496 --------------QIEVSFEIDANGILQVSA----------EDKGTGNKEKIVITNDQNRLTPE 536
                          :::|...::.:||..:|.          |:.|:..:..:...| |......
Mouse   482 VVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSLEADMECPN-QRPTESS 545

  Fly   537 DIDRMIR------------------------------------DAEKFAD--------------- 550
            |:|:.|:                                    ||:|..:
Mouse   546 DVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEESKTPDADKANEKKVDQPPEAKKPKIK 610

  Fly   551 ---------------------------------EDKKLKERVESRNELESYAYSLKNQIG----- 577
                                             :||..|||.:::|.:|...|..::::.
Mouse   611 VVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEK 675

  Fly   578 ----------------------------------DK-------------------------DKLG 583
                                              ||                         ::||
Mouse   676 FICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELG 740

  Fly   584 AKL--------------------SDDEKNKLESAIDESIKW------------LEQNPDADPEEY 616
            .:|                    .:.|..|:|.:::|.::|            |:|:|.....|.
Mouse   741 QRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEI 805

  Fly   617 KKQKKDLEAIVQPVIAKLYQGAGGAPPPE----------GGDDADLKDEL 656
            :.:.|:|..:.:||:.:        |.|:          .|.:.|.|::|
Mouse   806 RAKVKELNNVCEPVVTQ--------PKPKIESPKLERTPNGPNIDKKEDL 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	188/805 (23%)
Hsph1	XP_006504979.1	ASKHA_ATPase-like	56..400	CDD:483947	130/345 (38%)