DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-3 and Hsph1

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	XP_006504979.1	Gene:	Hsph1 / 15505	MGIID:	105053	Length:	877	Species:	Mus musculus

Alignment Length:	830	Identity:	194/830 - (23%)
Similarity:	322/830 - (38%)	Gaps:	276/830 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 SYVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPH 128
            |.::| ....|.||.|||||..|:..|||...||..||.::|..:|.:.:...:.:|. ||....
Mouse    56 SVISF-GSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVG 119

  Fly   129 ISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGL 193
            |.|........|:.|:|:||:|.|:|||||..|.|.||..|::||::|.||:|::..||..|.||
Mouse   120 IKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGL 184

  Fly   194 QVMRIINEPTAAAIAYGLDKK-----EGEKNVLVF-DLGGGTFDVSLLTIDNGVFEVVATNGDTH 252
            ..:|::|:.||.|:.||:.|:     |.:..|:|| |:|..:|.||....:.|..:|:.|..|..
Mouse   185 NCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPF 249

  Fly   253 LGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRAL-SGSHQVRIEIESFFEGD 316
            |||::||:::::||...:|.|...|.:...||:.:|.:|.||.|:.: |.|..:.:.||.|....
Mouse   250 LGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDK 314

  Fly   317 DFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGG 381
            |.|..:.|::||||..:|.:....|:..::....:..:||..|.:|||:||||.|::.:..|| |
Mouse   315 DVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKFF-G 378

  Fly   382 KEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGI-------ETVGGVMTKLIPR 439
            |:.|..:|.|||||.|.|:|..:||.........:.|..|..:.:       ||.|  :.::..|
Mouse   379 KDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEG--VHEVFSR 441

  Fly   440 NTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIP--------- 495
            |...|..|...|...                         |.|:|......|:|:|
Mouse   442 NHAAPFSKVLTFLRR-------------------------GPFELEAFYSDPQGVPYPEAKIGRF 481

  Fly   496 --------------QIEVSFEIDANGILQVSA----------EDKGTGNKEKIVITNDQNRLTPE 536
                          :::|...::.:||..:|.          |:.|:..:..:...| |......
Mouse   482 VVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSLEADMECPN-QRPTESS 545

  Fly   537 DIDRMIR------------------------------------DAEKFAD--------------- 550
            |:|:.|:                                    ||:|..:
Mouse   546 DVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEESKTPDADKANEKKVDQPPEAKKPKIK 610

  Fly   551 ---------------------------------EDKKLKERVESRNELESYAYSLKNQIG----- 577
                                             :||..|||.:::|.:|...|..::::.
Mouse   611 VVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEK 675

  Fly   578 ----------------------------------DK-------------------------DKLG 583
                                              ||                         ::||
Mouse   676 FICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELG 740

  Fly   584 AKL--------------------SDDEKNKLESAIDESIKW------------LEQNPDADPEEY 616
            .:|                    .:.|..|:|.:::|.::|            |:|:|.....|.
Mouse   741 QRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEI 805

  Fly   617 KKQKKDLEAIVQPVIAKLYQGAGGAPPPE----------GGDDADLKDEL 656
            :.:.|:|..:.:||:.:        |.|:          .|.:.|.|::|
Mouse   806 RAKVKELNNVCEPVVTQ--------PKPKIESPKLERTPNGPNIDKKEDL 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	130/345 (38%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	188/805 (23%)
Hsph1	XP_006504979.1	NBD_sugar-kinase_HSP70_actin	56..403	CDD:388382	130/348 (37%)
		FtsN	<537..>620	CDD:225629	8/83 (10%)
		DUF4127	<673..761	CDD:379257	5/87 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900