Protein Alignment Hsc70-3 and Hspa1l

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_038586.2
• Gene: Hspa1l / 15482
• MGIID: 96231
• Length: 641
• Species: Mus musculus
• Alignment Length: 617
• Identity: 381/617 - (61%)
• Similarity: 493/617 - (79%)
• Gaps: 5/617 - (0%)

  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |..||||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||:|||
Mouse     6 GMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPQNTV 69

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            |||||||||:::|..||.|:|.:||:|:.:..||.:.|......|.|.|||||:|||.|||||||
Mouse    70 FDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVMVSYKGEKKAFYPEEISSMVLTKMKETAE 134

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDK-KEGEKNVLV 222
            |:||..||:||:||||||||:||||||||||||||.|:||||||||||||||||| ..||::||:
Mouse   135 AFLGHNVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVLI 199

  Fly   223 FDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQK 287
            |||||||||||:||||:|:|||.||.|||||||||||.|::.||::.:|:|..|||.::.|||::
Mouse   200 FDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRR 264

  Fly   288 LRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMN 352
            ||...|:|||.||.|.|..:||:|.:||.||..::|||:||||..||||.||:||:|.|.||.|:
Mouse   265 LRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMD 329

  Fly   353 KKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIV 415
            |..:|:||||||||||||||:|::|:|.|::.::.|||||||||||||||.:|.|:  :....::
Mouse   330 KAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLL 394

  Fly   416 LLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLG 480
            ||||.||::|:||.|||||.||.||:.||||::|:|:|.||||..|.||||||||.||:||:|||
Mouse   395 LLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLG 459

  Fly   481 KFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDA 545
            :||||||||||||:|||||:|:|||||||.|:|.||.||...||.||||:.||:.|:|:||:::|
Mouse   460 RFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEIERMVQEA 524

  Fly   546 EKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPD 610
            |::..||:..:|::.::|.|||||:::|:.:|| :.|..|:|:.:|.|:....:|.:.|||.|..
Mouse   525 ERYKAEDEGQREKIAAKNALESYAFNMKSAVGD-EGLKDKISESDKKKILDKCNEVLSWLEANQL 588

  Fly   611 ADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAP 642
            |:.:|:..::|:||.:..|:|.||||.....|
Mouse   589 AEKDEFDHKRKELENMCNPIITKLYQSGCTGP 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	380/614 (62%)
Hspa1l	NP_038586.2	PTZ00009	3..641	CDD:240227	381/617 (62%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		257/382 (67%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		81/114 (71%)