DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-3 and Hspa8

DIOPT Version :9

Sequence 1:NP_001285139.1 Gene:Hsc70-3 / 32133 FlyBaseID:FBgn0001218 Length:656 Species:Drosophila melanogaster
Sequence 2:NP_112442.2 Gene:Hspa8 / 15481 MGIID:105384 Length:646 Species:Mus musculus


Alignment Length:634 Identity:402/634 - (63%)
Similarity:501/634 - (79%) Gaps:17/634 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |..:|||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||.|||
Mouse     4 GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNTV 67

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            |||||||||.:.|..||.|:|.:||.||....:|.:.|:.....|.|.|||:|:|||.||||.||
Mouse    68 FDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAE 132

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEG-EKNVLV 222
            |||||.||:|||||||||||:|||||||||.||||.|:||||||||||||||||||.| |:|||:
Mouse   133 AYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLI 197

  Fly   223 FDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQK 287
            |||||||||||:|||::|:|||.:|.|||||||||||.|:::|||..:|:|..|||.::.|||::
Mouse   198 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRR 262

  Fly   288 LRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMN 352
            ||...|:|||.||.|.|..|||:|.:||.||..::|||:|||||.||||.||.||:|.|.||.::
Mouse   263 LRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLD 327

  Fly   353 KKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIV 415
            |..:|:||||||||||||:|:|::|||.|||.::.|||||||||||||||.:|||:  ::...::
Mouse   328 KSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLL 392

  Fly   416 LLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLG 480
            ||||.||::||||.|||||.||.|||.||||::|.|:|.||||..|.||||||||.|||||:|||
Mouse   393 LLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLG 457

  Fly   481 KFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDA 545
            ||:||||||||||:|||||:|:|||||||.|||.||.||.:.||.||||:.||:.|||:||:::|
Mouse   458 KFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEA 522

  Fly   546 EKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPD 610
            ||:..||:|.:::|.|:|.|||||:::|..:.| :||..|::|::|.|:....:|.|.||::|..
Mouse   523 EKYKAEDEKQRDKVSSKNSLESYAFNMKATVED-EKLQGKINDEDKQKILDKCNEIISWLDKNQT 586

  Fly   611 ADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAP------------PPEGG 647
            |:.||::.|:|:||.:..|:|.||||.|||.|            ||.||
Mouse   587 AEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGG 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-3NP_001285139.1 HSPA5-like_NBD 29..403 CDD:212681 257/374 (69%)
PTZ00009 32..643 CDD:240227 397/625 (64%)
Hspa8NP_112442.2 PTZ00009 1..613 CDD:240227 393/610 (64%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 261/382 (68%)
Interaction with BAG1. /evidence=ECO:0000250 186..377 123/190 (65%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 85/114 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..646 8/22 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D288077at2759
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.730

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