Protein Alignment Hsc70-3 and Hspa8

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_112442.2
• Gene: Hspa8 / 15481
• MGIID: 105384
• Length: 646
• Species: Mus musculus
• Alignment Length: 634
• Identity: 402/634 - (63%)
• Similarity: 501/634 - (79%)
• Gaps: 17/634 - (2%)

  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |..:|||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||.|||
Mouse     4 GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNTV 67

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            |||||||||.:.|..||.|:|.:||.||....:|.:.|:.....|.|.|||:|:|||.||||.||
Mouse    68 FDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAE 132

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEG-EKNVLV 222
            |||||.||:|||||||||||:|||||||||.||||.|:||||||||||||||||||.| |:|||:
Mouse   133 AYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLI 197

  Fly   223 FDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQK 287
            |||||||||||:|||::|:|||.:|.|||||||||||.|:::|||..:|:|..|||.::.|||::
Mouse   198 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRR 262

  Fly   288 LRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMN 352
            ||...|:|||.||.|.|..|||:|.:||.||..::|||:|||||.||||.||.||:|.|.||.::
Mouse   263 LRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLD 327

  Fly   353 KKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIV 415
            |..:|:||||||||||||:|:|::|||.|||.::.|||||||||||||||.:|||:  ::...::
Mouse   328 KSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLL 392

  Fly   416 LLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLG 480
            ||||.||::||||.|||||.||.|||.||||::|.|:|.||||..|.||||||||.|||||:|||
Mouse   393 LLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLG 457

  Fly   481 KFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDA 545
            ||:||||||||||:|||||:|:|||||||.|||.||.||.:.||.||||:.||:.|||:||:::|
Mouse   458 KFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEA 522

  Fly   546 EKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPD 610
            ||:..||:|.:::|.|:|.|||||:::|..:.| :||..|::|::|.|:....:|.|.||::|..
Mouse   523 EKYKAEDEKQRDKVSSKNSLESYAFNMKATVED-EKLQGKINDEDKQKILDKCNEIISWLDKNQT 586

  Fly   611 ADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAP------------PPEGG 647
            |:.||::.|:|:||.:..|:|.||||.|||.|            ||.||
Mouse   587 AEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGG 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	397/625 (64%)
Hspa8	NP_112442.2	PTZ00009	1..613	CDD:240227	393/610 (64%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		261/382 (68%)
		Interaction with BAG1. /evidence=ECO:0000250	186..377		123/190 (65%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		85/114 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..646		8/22 (36%)