Protein Alignment Hsc70-3 and Grp170

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: XP_321225.4
• Gene: Grp170 / 1281282
• VectorBaseID: AGAMI1_004700
• Length: 975
• Species: Anopheles gambiae
• Alignment Length: 713
• Identity: 187/713 - (26%)
• Similarity: 305/713 - (42%)
• Gaps: 122/713 - (17%)

  Fly     1 MKLCILLAVVA-FVGLSLGEEKKEKDKELGTVIGIDLGTTYSCVGVYKNG-RVEIIANDQGNRIT 63
            |.|.:|..||| |..|:          ....|:.:|||:.:..|||...| .:||..|.:..|.|
Mosquito    13 MLLIVLPMVVALFATLA----------NSAAVMSVDLGSEWMKVGVVSPGVPMEIALNKESKRKT 67

  Fly    64 PSYVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPH 128
            |:.:|| .:|:|:.|:.|:......|.|:......|:|:...:..|....|.||:..:..:....
Mosquito    68 PTTIAF-RNGDRVFGEDAQTLGVRFPSNSFGYLTDLLGKTVDNPMVDLYRKRFPYYDIVADPVRR 131

  Fly   129 ISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGL 193
            ..|..| |.:.:..||:.|.:|...|..||...|:.:|..|:.||.::..|:|.|...|..:|.|
Mosquito   132 TVVFRS-GEEQYMIEELIAQLLQVAKSYAEDSTGQLITECVLIVPGFYGQAERTALVAAARLANL 195

  Fly   194 QVMRIINEPTAAAIAYGLDKK----EGEKNVLVFDLGGGTFDVSLLTID----------NGVFEV 244
            :|:::||:.||.|:.||:.::    |..:..|.:|:|......::::..          :.|.:|
Mosquito   196 KVLQLINDYTAVALNYGIFRRKEINETAQYFLFYDMGAYKTSAAVVSYQLVKDKATRETHPVVQV 260

  Fly   245 VATNGDTHLGGEDFDQRVMDHFIKLYKK--KKGKDIRKDNRAVQKLRREVEKAKRALSGSHQVRI 307
            :....|..|||.:...|:.|:..:.:.|  |...|:..:.||:.||.:|..:.|..||.:.:...
Mosquito   261 LGVGYDRTLGGLEMQVRLRDYLGREFNKMGKTKTDVFTNPRAMAKLFKEAGRLKNVLSANTEHYA 325

  Fly   308 EIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQ 372
            :||...:..||...:.|.:||||..||:.....|:.|.|..:.:....::::||.||:||:||||
Mosquito   326 QIEGLLDEQDFRLLVKREQFEELCKDLYERVTAPLDKALAVSGLALDVINQVVLFGGNTRVPKVQ 390

  Fly   373 QLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLD--VNPLTMGIETVGGVMTK 435
            .:::... |:|.::.:|.|||...||..:|..|:........:..|  :.|:.:..:..|.....
Mosquito   391 DILRTHI-GQELAKNLNADEAACMGAVYRAADLATGFKVKKFITKDAVLFPIQVVFDREGESGAT 454

  Fly   436 LIPRNTVI------PTKKSQVFSTASDNQHT----VTIQVYEGERPMTKDNHLLGKFDLTGIPPA 490
            ...|.|:.      |.||...|     |:||    .|:|..|.:..:..|...||..||..:..:
Mosquito   455 RQVRRTLFGSMNSYPQKKVITF-----NKHTDDFEFTVQYAELDAVLKGDTETLGSPDLARVQLS 514

  Fly   491 ---------------PRGIPQIEVSFEIDANGILQVSAED---KGTGNKEKIVITNDQNRLTPED 537
                           .:|   |:..|.:|.:||..::..:   :.|..||:    .|::..|.:.
Mosquito   515 EVAKRLKASVAENVESKG---IKAHFLLDDSGIFSLANVELVLEKTVTKEE----EDEDESTFQK 572

  Fly   538 IDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDE-----KNKLESA 597
            |...|.........||..:|:..:..                   ||:..|:|     |...|||
Mosquito   573 IGNTISKLFSGDSADKPAEEKPPTEG-------------------GAEAKDEEEPASGKEGKESA 618

  Fly   598 IDESIKWLEQNPDADPEEYKKQK-KDLEAIVQPVIAKLYQGAGGA--PPPEGGDDADLK--DE 655
                    |:......||.|||. ||.||            .|||  ..||.|:.||.|  ||
Mosquito   619 --------EEEQQQQQEEGKKQSAKDKEA------------DGGAKDAKPEAGEPADKKAADE 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	170/665 (26%)
Grp170	XP_321225.4	None