DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-3 and Hyou1

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_067370.3	Gene:	Hyou1 / 12282	MGIID:	108030	Length:	999	Species:	Mus musculus

Alignment Length:	710	Identity:	194/710 - (27%)
Similarity:	317/710 - (44%)	Gaps:	130/710 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LC-ILLAVVAFVGLSLGEEKKEKDKELGTVIGIDLGTTYSCVGVYKNG-RVEIIANDQGNRITPS 65
            || .|:||:....|:|.:..        .|:.:|||:....|.:.|.| .:||:.|.:..|.||.
Mouse    14 LCWALVAVLLADLLALSDTL--------AVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPV 70

  Fly    66 YVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNV--------QHDIKFFPFK-VV 121
            .|.. .:.||.:||:|......||:.|:...:.|:|::..:.:|        :|::...|.: .|
Mouse    71 TVTL-KENERFLGDSAAGMAIKNPKATLRYFQHLLGKQADNPHVALYRSRFPEHELIVDPQRQTV 134

  Fly   122 EKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKD 186
            .....|.:.         |:|||:..|||...:..||.:..:.:..||:||||:||.|:|:|...
Mouse   135 RFQISPQLQ---------FSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPAFFNQAERRAVLQ 190

  Fly   187 AGVIAGLQVMRIINEPTAAAIAYGL----DKKEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVAT 247
            |..:|||:|:::||:.||.|::||:    |.....:||:.:|:|.|:...:::|     ::.|.|
Mouse   191 AARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQNVMFYDMGSGSTVCTIVT-----YQTVKT 250

  Fly   248 NG--------------DTHLGGEDFDQRVMDHFIKLY----KKKKGKDIRKDNRAVQKLRREVEK 294
            ..              |..|||.:.:.|:.:|..||:    |.:|.||:|::.||:.||.||..:
Mouse   251 KEAGMQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQRKGQKAKDVRENPRAMAKLLREANR 315

  Fly   295 AKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEI 359
            .|..||.:.....:||...:..||...:||.:||||..|||.....|||:.|:.|:|:...:.::
Mouse   316 LKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFDRVPGPVQQALQSAEMSLDQIEQV 380

  Fly   360 VLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLD--VNPL 422
            :||||:||:||||:::....|.:|..:.||.|||.|.||..||..||........|:.|  :.|:
Mouse   381 ILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPI 445

  Fly   423 ----TMGIETVGGVMT------KLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPM--TKD 475
                |..:|...|:.:      .|..|....|.:|...|:..|   |.....:..|:...  .:|
Mouse   446 LVEFTREVEEEPGLRSLKHNKRVLFSRMGPYPQRKVITFNRYS---HDFNFHINYGDLGFLGPED 507

  Fly   476 NHLLGKFDLT-----GIPPAPRGIPQ-----IEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQ 530
            ..:.|..:||     |:..:.:..|.     |:..|.:|.:|:|
Mouse   508 LRVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHFNLDESGVL--------------------- 551

  Fly   531 NRLTPEDIDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLE 595
                  .:||:          :...:..||...|.||....|.|.|  ....|...|.|.|....
Mouse   552 ------SLDRV----------ESVFETLVEDSPEEESTLTKLGNTI--SSLFGGGTSSDAKENGT 598

  Fly   596 SAIDESIKWLEQNPDADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGGDDADLKDE 655
            .|:.|.    |::|....::...::.:|:...:|...:..|    .||.|...||..:.|
Mouse   599 DAVQEE----EESPAEGSKDEPAEQGELKEEAEPPAEETSQ----PPPSEPKGDAAREGE 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	132/405 (33%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	180/666 (27%)
Hyou1	NP_067370.3	HYOU1-like_NBD	36..424	CDD:212672	131/402 (33%)
		MDN1	<554..767	CDD:227596	27/117 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..694		23/94 (24%)
		PHA03169	<586..>691	CDD:223003	17/73 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..999
		Prevents secretion from ER. /evidence=ECO:0000255	996..999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900