DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-3 and HSPH1

DIOPT Version :9

Sequence 1:NP_001285139.1 Gene:Hsc70-3 / 32133 FlyBaseID:FBgn0001218 Length:656 Species:Drosophila melanogaster
Sequence 2:NP_001273433.1 Gene:HSPH1 / 10808 HGNCID:16969 Length:860 Species:Homo sapiens


Alignment Length:826 Identity:195/826 - (23%)
Similarity:326/826 - (39%) Gaps:271/826 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 SYVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPH 128
            |.::| ....|.||.|||||..|:..|||.:.||..||.::|..:|.:.:...:.:|. ||....
Human    39 SVISF-GSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVG 102

  Fly   129 ISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGL 193
            |.|.......:|:.|:|:||:|.|:|||||..|.|.||..|::||::|.||:|::..||..|.||
Human   103 IKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGL 167

  Fly   194 QVMRIINEPTAAAIAYGLDKKE----GEK-NVLVF-DLGGGTFDVSLLTIDNGVFEVVATNGDTH 252
            ..:|::|:.||.|:.||:.|::    .|| .::|| |:|...|.||....:.|..:|:.|..|..
Human   168 NCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPF 232

  Fly   253 LGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRAL-SGSHQVRIEIESFFEGD 316
            |||::||:::::||...:|.|...|.:...||:.:|.:|.||.|:.: |.|..:.:.||.|....
Human   233 LGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDK 297

  Fly   317 DFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGG 381
            |.|..:.|::||||..:|.:....|:..:||...:..:||..:.:|||:||||.|::.:..|| |
Human   298 DVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFF-G 361

  Fly   382 KEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGI------ETVGGVMTKLIPRN 440
            |:.|..:|.|||||.|.|:|..:||.........:.|..|..:.:      |...|| .::..||
Human   362 KDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGV-HEVFSRN 425

  Fly   441 TVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIP---------- 495
            ...|..|...|...                         |.|:|......|:|:|          
Human   426 HAAPFSKVLTFLRR-------------------------GPFELEAFYSDPQGVPYPEAKIGRFV 465

  Fly   496 -------------QIEVSFEIDANGILQVSA---------------------------------- 513
                         :::|...::.:||..:|.                                  
Human   466 VQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTD 530

  Fly   514 -----EDKGTGNKEKI--------------VITNDQNRLTPED---------------------- 537
                 ::...|.:.::              .:|:::|::...|                      
Human   531 KNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVN 595

  Fly   538 -----------------IDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQI--------- 576
                             ::..|....|...:||..|||.:::|.:|.|.|..::::         
Human   596 VELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFIC 660

  Fly   577 ------------------------------GDK-------------------------DKLGAKL 586
                                          .||                         ::||.:|
Human   661 EQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRL 725

  Fly   587 -----------SDDEK---------NKLESAIDESIKW------------LEQNPDADPEEYKKQ 619
                       :.|||         .|:|.:::|.::|            |:|:|....:|.|.:
Human   726 QHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTK 790

  Fly   620 KKDLEAIVQPVIAKLYQGAGGAPPPE----------GGDDADLKDE 655
            .|:|....:||:.:        |.|:          .|.:.|.|:|
Human   791 IKELNNTCEPVVTQ--------PKPKIESPKLERTPNGPNIDKKEE 828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-3NP_001285139.1 HSPA5-like_NBD 29..403 CDD:212681 131/345 (38%)
PTZ00009 32..643 CDD:240227 189/802 (24%)
HSPH1NP_001273433.1 NBD_sugar-kinase_HSP70_actin 39..386 CDD:327376 131/348 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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