Protein Alignment Hsc70-3 and HSPH1

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_001273433.1
• Gene: HSPH1 / 10808
• HGNCID: 16969
• Length: 860
• Species: Homo sapiens
• Alignment Length: 826
• Identity: 195/826 - (23%)
• Similarity: 326/826 - (39%)
• Gaps: 271/826 - (32%)

  Fly    65 SYVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPH 128
            |.::| ....|.||.|||||..|:..|||.:.||..||.::|..:|.:.:...:.:|. ||....
Human    39 SVISF-GSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVG 102

  Fly   129 ISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGL 193
            |.|.......:|:.|:|:||:|.|:|||||..|.|.||..|::||::|.||:|::..||..|.||
Human   103 IKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGL 167

  Fly   194 QVMRIINEPTAAAIAYGLDKKE----GEK-NVLVF-DLGGGTFDVSLLTIDNGVFEVVATNGDTH 252
            ..:|::|:.||.|:.||:.|::    .|| .::|| |:|...|.||....:.|..:|:.|..|..
Human   168 NCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPF 232

  Fly   253 LGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRAL-SGSHQVRIEIESFFEGD 316
            |||::||:::::||...:|.|...|.:...||:.:|.:|.||.|:.: |.|..:.:.||.|....
Human   233 LGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDK 297

  Fly   317 DFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGG 381
            |.|..:.|::||||..:|.:....|:..:||...:..:||..:.:|||:||||.|::.:..|| |
Human   298 DVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFF-G 361

  Fly   382 KEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGI------ETVGGVMTKLIPRN 440
            |:.|..:|.|||||.|.|:|..:||.........:.|..|..:.:      |...|| .::..||
Human   362 KDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGV-HEVFSRN 425

  Fly   441 TVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIP---------- 495
            ...|..|...|...                         |.|:|......|:|:|
Human   426 HAAPFSKVLTFLRR-------------------------GPFELEAFYSDPQGVPYPEAKIGRFV 465

  Fly   496 -------------QIEVSFEIDANGILQVSA---------------------------------- 513
                         :::|...::.:||..:|.
Human   466 VQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTD 530

  Fly   514 -----EDKGTGNKEKI--------------VITNDQNRLTPED---------------------- 537
                 ::...|.:.::              .:|:::|::...|
Human   531 KNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVN 595

  Fly   538 -----------------IDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQI--------- 576
                             ::..|....|...:||..|||.:::|.:|.|.|..::::
Human   596 VELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFIC 660

  Fly   577 ------------------------------GDK-------------------------DKLGAKL 586
                                          .||                         ::||.:|
Human   661 EQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRL 725

  Fly   587 -----------SDDEK---------NKLESAIDESIKW------------LEQNPDADPEEYKKQ 619
                       :.|||         .|:|.:::|.::|            |:|:|....:|.|.:
Human   726 QHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTK 790

  Fly   620 KKDLEAIVQPVIAKLYQGAGGAPPPE----------GGDDADLKDE 655
            .|:|....:||:.:        |.|:          .|.:.|.|:|
Human   791 IKELNNTCEPVVTQ--------PKPKIESPKLERTPNGPNIDKKEE 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	189/802 (24%)
HSPH1	NP_001273433.1	ASKHA_NBD_HSP70_HSPH1	39..383	CDD:466845	131/345 (38%)