DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and HYOU1

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	XP_005271449.1	Gene:	HYOU1 / 10525	HGNCID:	16931	Length:	1000	Species:	Homo sapiens

Alignment Length:	694	Identity:	191/694 - (27%)
Similarity:	326/694 - (46%)	Gaps:	123/694 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VIGIDLGTTYSCVGVYKNG-RVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            |:.:|||:....|.:.|.| .:||:.|.:..|.||..|.. .:.||..||:|.:....||:.|:.
Human    35 VMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTL-KENERFFGDSAASMAIKNPKATLR 98

  Fly    95 DAKRLIGREWSDTNV--------QHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLG 151
            ..:.|:|::..:.:|        :|::.|.|     :....|..:.:.   ..|:|||:..|||.
Human    99 YFQHLLGKQADNPHVALYQARFPEHELTFDP-----QRQTVHFQISSQ---LQFSPEEVLGMVLN 155

  Fly   152 KMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEG 216
            ..:..||.:..:.:..||:|||.:||.|:|:|...|..:|||:|:::||:.||.|::||:.:::.
Human   156 YSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKD 220

  Fly   217 ----EKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNG--------------DTHLGGEDFDQRVM 263
                .:|::.:|:|.|:...:::|     :::|.|..              |..|||.:.:.|:.
Human   221 INTTAQNIMFYDMGSGSTVCTIVT-----YQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLR 280

  Fly   264 DHFIKLY----KKKKGKDIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTR 324
            :....|:    |.::.||:|::.||:.||.||..:.|..||.:.....:||...:..||...:||
Human   281 ERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTR 345

  Fly   325 AKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGIN 389
            .:||||..|||.....|||:.|:.|:|:..::.:::||||:||:|:||:::....|.:|..:.||
Human   346 VEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNIN 410

  Fly   390 PDEAVAYGAAVQAGVLSGEQDTDAIVLLD--VNPL----TMGIETVGGVMT------KLIPRNTV 442
            .|||.|.||..||..||........|:.|  |.|:    |..:|...|:.:      .|..|...
Human   411 ADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGP 475

  Fly   443 IPTKKSQVFSTASDNQHTVTIQVYEGERPM--TKDNHLLGKFDLT-----GIPPAPRGIPQ---- 496
            .|.:|...|:..|   |.....:..|:...  .:|..:.|..:||     |:..:.:..|.
Human   476 YPQRKVITFNRYS---HDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESK 537

  Fly   497 -IEVSFEIDANGILQV-------------SAEDKGTGNKEKIVITNDQNRL-----TPEDIDRMI 542
             |:..|.:|.:|:|.:             |||::.|..|    :.|..:.|     ||
Human   538 GIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTK----LGNTISSLFGGGTTP------- 591

  Fly   543 RDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQ 607
             ||::...:  .::|..||..|            |.||:.|.::  :.|.:.|:.:::..:....
Human   592 -DAKENGTD--TVQEEEESPAE------------GSKDEPGEQV--ELKEEAEAPVEDGSQPPPP 639

  Fly   608 NP--DADPEEYKKQKKDL--EAIVQPVIAKLYQGAGG-APPPEG 646
            .|  ||.||..|..:|:.  ::..|....|...|..| ||.|||
Human   640 EPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEG 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	125/402 (31%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	186/688 (27%)
HYOU1	XP_005271449.1	HSP70	35..672	CDD:278441	184/681 (27%)
		NBD_sugar-kinase_HSP70_actin	36..424	CDD:302596	124/401 (31%)
		PHA00666	601..>739	CDD:222808	26/97 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810