Protein Alignment Hsc70-3 and HYOU1

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_001397970.1
• Gene: HYOU1 / 10525
• HGNCID: 16931
• Length: 1000
• Species: Homo sapiens
• Alignment Length: 694
• Identity: 191/694 - (27%)
• Similarity: 326/694 - (46%)
• Gaps: 123/694 - (17%)

  Fly    31 VIGIDLGTTYSCVGVYKNG-RVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            |:.:|||:....|.:.|.| .:||:.|.:..|.||..|.. .:.||..||:|.:....||:.|:.
Human    35 VMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTL-KENERFFGDSAASMAIKNPKATLR 98

  Fly    95 DAKRLIGREWSDTNV--------QHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLG 151
            ..:.|:|::..:.:|        :|::.|.|     :....|..:.:.   ..|:|||:..|||.
Human    99 YFQHLLGKQADNPHVALYQARFPEHELTFDP-----QRQTVHFQISSQ---LQFSPEEVLGMVLN 155

  Fly   152 KMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEG 216
            ..:..||.:..:.:..||:|||.:||.|:|:|...|..:|||:|:::||:.||.|::||:.:::.
Human   156 YSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKD 220

  Fly   217 ----EKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNG--------------DTHLGGEDFDQRVM 263
                .:|::.:|:|.|:...:::|     :::|.|..              |..|||.:.:.|:.
Human   221 INTTAQNIMFYDMGSGSTVCTIVT-----YQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLR 280

  Fly   264 DHFIKLY----KKKKGKDIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTR 324
            :....|:    |.::.||:|::.||:.||.||..:.|..||.:.....:||...:..||...:||
Human   281 ERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTR 345

  Fly   325 AKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGIN 389
            .:||||..|||.....|||:.|:.|:|:..::.:::||||:||:|:||:::....|.:|..:.||
Human   346 VEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNIN 410

  Fly   390 PDEAVAYGAAVQAGVLSGEQDTDAIVLLD--VNPL----TMGIETVGGVMT------KLIPRNTV 442
            .|||.|.||..||..||........|:.|  |.|:    |..:|...|:.:      .|..|...
Human   411 ADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGP 475

  Fly   443 IPTKKSQVFSTASDNQHTVTIQVYEGERPM--TKDNHLLGKFDLT-----GIPPAPRGIPQ---- 496
            .|.:|...|:..|   |.....:..|:...  .:|..:.|..:||     |:..:.:..|.
Human   476 YPQRKVITFNRYS---HDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESK 537

  Fly   497 -IEVSFEIDANGILQV-------------SAEDKGTGNKEKIVITNDQNRL-----TPEDIDRMI 542
             |:..|.:|.:|:|.:             |||::.|..|    :.|..:.|     ||
Human   538 GIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTK----LGNTISSLFGGGTTP------- 591

  Fly   543 RDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQ 607
             ||::...:  .::|..||..|            |.||:.|.::  :.|.:.|:.:::..:....
Human   592 -DAKENGTD--TVQEEEESPAE------------GSKDEPGEQV--ELKEEAEAPVEDGSQPPPP 639

  Fly   608 NP--DADPEEYKKQKKDL--EAIVQPVIAKLYQGAGG-APPPEG 646
            .|  ||.||..|..:|:.  ::..|....|...|..| ||.|||
Human   640 EPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEG 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	186/688 (27%)
HYOU1	NP_001397970.1	ASKHA_NBD_HSP70_HYOU1	34..424	CDD:466828	125/402 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	578..694		32/130 (25%)
		LGT	<593..694	CDD:469786	27/107 (25%)
		Prevents secretion from ER. /evidence=ECO:0000255	997..1000