Protein Alignment CG9360 and DHRS1

DIOPT Version :10

• Sequence 1: NP_572746.1
• Gene: CG9360 / 32128
• FlyBaseID: FBgn0030332
• Length: 251
• Species: Drosophila melanogaster
• Sequence 2: NP_612461.1
• Gene: DHRS1 / 115817
• HGNCID: 16445
• Length: 313
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 73/269 - (27%)
• Similarity: 97/269 - (36%)
• Gaps: 69/269 - (25%)

  Fly     7 RVAVVTGASSGIGAACCKDLVSKGLVVVGLARREDRLQELKASLPADQASRFHGR----KCDVSQ 67
            :|.||||||.|||......|...|..|....|..|.|:     :.|.:|....|:    .||.||
Human     8 QVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLR-----VVAQEAQSLGGQCVPVVCDSSQ 67

  Fly    68 EQEVIDAFAWID-ATLGGADVLVNNAGIVRLGVGITHEGNGADLRAILDTNVLGVSWCTREAFKS 131
            |.||...|..:| ...|..|||||||              .|.::.||:|.        .:||..
Human    68 ESEVRSLFEQVDREQQGRLDVLVNNA--------------YAGVQTILNTR--------NKAFWE 110

  Fly   132 LKRRNVND-------GHILIVNSVAGHR-----------VINNPGITMGM----YSPSKYAVTAL 174
            ......:|       ||...  ||.|.|           ||::||....|    |...|.|...|
Human   111 TPASMWDDINNVGLRGHYFC--SVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKL 173

  Fly   175 TEVLRQEFHNNKTQTKITSISPGAVDTEIID----KEALVGIPDFPMLR----SEDVADAISYCI 231
            ......|...:  .....|:.||.|.||::.    ||.::..|.....:    |.:..:....|:
Human   174 AADCAHELRRH--GVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCV 236

  Fly   232 ---QTPPNV 237
               .|.||:
Human   237 VALATDPNI 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9360	NP_572746.1	Rossmann-fold NAD(P)(+)-binding proteins	1..246	CDD:473865	73/269 (27%)
DHRS1	NP_612461.1	DHRS1-like_SDR_c	5..271	CDD:187664	73/269 (27%)
		Required for ER localization. /evidence=ECO:0000269|PubMed:30031147	235..313		4/11 (36%)