Protein Alignment CG15221 and Sv2a

DIOPT Version :9

• Sequence 1: NP_001096957.1
• Gene: CG15221 / 32127
• FlyBaseID: FBgn0030331
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_071313.1
• Gene: Sv2a / 64051
• MGIID: 1927139
• Length: 742
• Species: Mus musculus
• Alignment Length: 614
• Identity: 140/614 - (22%)
• Similarity: 236/614 - (38%)
• Gaps: 129/614 - (21%)

  Fly    19 GGREENLSEKPR---PHTFEEAITLTGVGRFHYKLLLICGLCFMGVMVEIMGVSLIMNQMKCDLQ 80
            |||.|....|.|   ...:|..:...|.|||.:.|..:.||..|...||:..|..::...:.|:.
Mouse   134 GGRGEAQRRKDREELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMC 198

  Fly    81 PTLNQQGILASAGFLGVVLSSHAMGFLADTWGRATTLRYALCISSVCSIVSAFSVNIWMLIVFRF 145
            .:.:.:|:|....:||:::.:...|.|||..||...|..:|.::||.:..|:|.......:..|.
Mouse   199 LSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRL 263

  Fly   146 LTGFFISGGQACVFSLCGEFHGTGSRIRHVTLLSGFLCMAMIFAPAMAIGILPLRIETIVLG--M 208
            |:|..|.|....|||...||.....|..|::.|..|..:..::|.|||..|:|....:..:|  .
Mouse   264 LSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAY 328

  Fly   209 HFSSWRVLLLANVSIPLLALVGISALPETPKYLLVQGRGDESLEVLRSIFANN---SGRDPSEYP 270
            .|.||||.:|......:.|:..::..||:|::.|..|:.||:..||:.:...|   .|.....:.
Mouse   329 QFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFS 393

  Fly   271 VK------------EVALESG------GVSLSDVHGFLDAVRLVWHQTVPLF---YRARLWHTLN 314
            |.            |:..::|      ||....:.|      .||...:..|   || |:  ||.
Mouse   394 VTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGG------QVWGNFLSCFSPEYR-RI--TLM 449

  Fly   315 ICCIQFIIYFLAQGIFMWFPTILDELGT-----------------------------RNGE---- 346
            :..:.|.:.|...|:.:|||.::..|..                             |.|:
Mouse   450 MMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFND 514

  Fly   347 ----------------------------NTLL--CTVLQG--FN-------------INSSSEDE 366
                                        ||..  ||.:..  :|             :||:....
Mouse   515 KFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHN 579

  Fly   367 ASSCSVEVDTST----YQVMIIIAACFVVIY---LIFAYIIDYMGKKNLLMAWMVLTMICLVALH 424
            ...|.::| |.|    |.|..:.....:.:.   ::.|.::|.:|:..:|....||:.:....|.
Mouse   580 KEGCPLDV-TGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLS 643

  Fly   425 Y--VEQFALVVIALTVVMAIGNCGGLVSTIAMEFYPTHINAMGMCFIMMVGRLGAVVGSNILGRL 487
            :  .|...:.::.|...::|.:...| ..:.:|.||:........|:..:.:|.||:|.:|....
Mouse   644 FGNSESAMIALLCLFGGVSIASWNAL-DVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSF 707

  Fly   488 L-FASCDPIFWALLALVVLLCTLGYFLPE 515
            : .....||.:|..|| .|..:|...|||
Mouse   708 VGITKAAPILFASAAL-ALGSSLALKLPE 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15221	NP_001096957.1	2A0115	36..488	CDD:273327	123/564 (22%)
		MFS	51..488	CDD:119392	118/549 (21%)
Sv2a	NP_071313.1	synapt_SV2	1..742	CDD:130366	140/614 (23%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..145		5/10 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8715
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910