DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15221 and SLC22A25

DIOPT Version :9

Sequence 1:	NP_001096957.1	Gene:	CG15221 / 32127	FlyBaseID:	FBgn0030331	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_016873173.1	Gene:	SLC22A25 / 387601	HGNCID:	32935	Length:	577	Species:	Homo sapiens

Alignment Length:	517	Identity:	104/517 - (20%)
Similarity:	171/517 - (33%)	Gaps:	177/517 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 CDLQPTLNQQGILASAGFL---GVVLSSHAMGFLADT---------------------------- 110
            |:.|| ||     :.|.||   |:::..:..|.|:|.
Human   139 CESQP-LN-----SVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHVSTDCDEGLEVPIAIHQHHV 197

  Fly   111 -W-GRATTLRYALCISSVCSIVSAFSVNIWMLIVFRFLTG---FFI---------------SGGQ 155
             | ||...||::....::....:||:..|.:....|||.|   |.|               ....
Human   198 FWFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAM 262

  Fly   156 ACVFSLCGEFHGTGSRIRHVTLLS-GFL----CMAMIF--APAMAIGILPLRIETIVLGMHFSSW 213
            |...:||      .:.|.|:||.| .|:    |:..:.  ||.....:             ||.|
Human   263 ALTLTLC------AASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFL-------------FSRW 308

  Fly   214 RVLLLANVSIPLLALVGISALPETPKYLLVQGRGDESLEVLRSIFANNSGRDPSEYPVKEVALES 278
                                |.|:.::|::..:.:|.|:.||.....|..::..:....||...:
Human   309 --------------------LAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKST 353

  Fly   279 GGVSLSDV---HGFLDAVRLVWHQTVPLFYRARLWHTLNICCIQFIIYFLAQGIFMWFPTI-LDE 339
            ....|...   |...:.:|      :|...:       .||.:.|:.:  |..|..|..|: |..
Human   354 MKQELEAAQKKHSLCELLR------IPNICK-------RICFLSFVRF--ASTIPFWGLTLHLQH 403

  Fly   340 LGTRNGENTLLCTVLQGFNINSSSEDEASSCSVEVDTSTYQVMIIIAACFVVIYLIFAYIIDYMG 404
            |    |.|..|...|.|                        .:.::|.|      :..:.:::|.
Human   404 L----GNNVFLLQTLFG------------------------AVTLLANC------VAPWALNHMS 434

  Fly   405 KKNLLMAWMVLTMICLVALHYV--EQFALVVIALTVVMAIGNCGGLVSTI-AMEFYPTHINAMGM 466
            ::...|..|.|...||:|:.:|  |...|.|:..|:.:...:.|...||. ..|..|:.|.
Human   435 RRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIR---- 495

  Fly   467 CFIMMVGRLGAVVG--SNILGRL------LFASCDPIFWALLALVVLLCTLGYFLPEKARSQ 520
                  ||...:.|  :||.|.|      |.....|:.|.:..:..:|..|...|..:.|:|
Human   496 ------GRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQ 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15221	NP_001096957.1	2A0115	36..488	CDD:273327	96/483 (20%)
CG15221	NP_001096957.1	MFS	51..488	CDD:119392	96/483 (20%)
SLC22A25	XP_016873173.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153356
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840