DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15221 and SV2C

DIOPT Version :9

Sequence 1:	NP_001096957.1	Gene:	CG15221 / 32127	FlyBaseID:	FBgn0030331	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_055794.3	Gene:	SV2C / 22987	HGNCID:	30670	Length:	727	Species:	Homo sapiens

Alignment Length:	621	Identity:	147/621 - (23%)
Similarity:	250/621 - (40%)	Gaps:	129/621 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 REFANMEGGREENLSEKPRPHTFEEAITLTGVGRFHYKLLLICGLCFMGVMVEIMGVSLIMNQMK 76
            ||..:.....||.|:::     :|..|...|.|||.:.|..:.|:..|...||:..|..::...:
Human   121 RELESERRADEEELAQQ-----YELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE 180

  Fly    77 CDLQPTLNQQGILASAGFLGVVLSSHAMGFLADTWGRATTLRYALCISSVCSIVSAFSVNIWMLI 141
            .||....:..|.|.|..:||:::.:...|.|||..||..:|...:.::...:.:|:|.......:
Human   181 TDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFL 245

  Fly   142 VFRFLTGFFISGGQACVFSLCGEFHGTGSRIRHVTLLSGFLCMAMIFAPAMAIGILPLRIETIVL 206
            ..|.|:||.|.|....|||...|......|..|::.|..|..:..|:|.|||..|:|....:..:
Human   246 FCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSM 310

  Fly   207 G--MHFSSWRVLLLANVSIPLL-ALVGISALPETPKYLLVQGRGDESLEVLRSIFANN---SGRD 265
            |  ..|.||||.::. .::|.: ::|.::.:||:|::||..|:.||:..:|:.|...|   .|:.
Human   311 GSAYQFHSWRVFVIV-CALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQP 374

  Fly   266 PSEYPVKEVALESGGVSLSDVHGFLDAVRLVWHQTVPLFYRAR-----LW-------------HT 312
            ...:.|.::........|.::    ::....|::.  .|.|.|     :|             :|
Human   375 EKVFTVNKIKTPKQIDELIEI----ESDTGTWYRR--CFVRIRTELYGIWLTFMRCFNYPVRDNT 433

  Fly   313 LNICCIQFIIYFLAQGIFMWFPTIL-----DE--LGTRNGE------------------------ 346
            :.:..:.|.:.|...|:.:|||.::     ||  |.|||.|
Human   434 IKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYD 498

  Fly   347 ------------------------------NTLL--CTVLQGFNINSSSE------DEASSCS-- 371
                                          ||..  ||.:.....|:..|      .|..:||
Human   499 NGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFF 563

  Fly   372 ---------VEVDTSTYQVMII-IAACFVVI--YLIFAYIIDYMGKKNLLMAWMVLTMICLVALH 424
                     .:.|.|.|.:..: ......|:  .::.|.::|.:|:..:|...|||:.|....|.
Human   564 HNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLW 628

  Fly   425 Y--VEQFALVVIALTVVMAIGNCGGLVSTIAMEFYPTHINAMGMCFIMMVGRLGAVVGSNILGRL 487
            :  .|...:.::.|...:.|.....| ..:.:|.|||...|.|..|:..:.:..||:|:.|.|.|
Human   629 FGTSESMMIGMLCLYNGLTISAWNSL-DVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSL 692

  Fly   488 L-FASCDPIFWALLALVVLLC--TLGYFLPEKARSQ 520
            : .....||   |||..||:|  .:|..||: .|:|
Human   693 VSITKSIPI---LLASTVLVCGGLVGLCLPD-TRTQ 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15221	NP_001096957.1	2A0115	36..488	CDD:273327	127/560 (23%)
CG15221	NP_001096957.1	MFS	51..488	CDD:119392	121/545 (22%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	147/621 (24%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		2/6 (33%)
		MFS	155..719	CDD:119392	131/574 (23%)
		Pentapeptide_3	507..561	CDD:290309	7/53 (13%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:27294781	519..563		9/43 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5591
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208328at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870