DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15221 and sv2a

DIOPT Version :9

Sequence 1:	NP_001096957.1	Gene:	CG15221 / 32127	FlyBaseID:	FBgn0030331	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_012825002.1	Gene:	sv2a / 100379721	XenbaseID:	XB-GENE-968429	Length:	729	Species:	Xenopus tropicalis

Alignment Length:	612	Identity:	136/612 - (22%)
Similarity:	238/612 - (38%)	Gaps:	118/612 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 REFANMEGGREENLSEKPRPHTFEEAITLTGVGRFHYKLLLICGLCFMGVMVEIMGVSLIMNQMK 76
            ::|.::||.|:::..|..:  .:|..:...|.|||.:.|..:.||..|...|||..|..::...:
Frog   119 KDFNDLEGQRKKDKEELAQ--QYEVILQECGHGRFQWTLYFVLGLALMADGVEIFVVGFVLPSAE 181

  Fly    77 CDLQPTLNQQGILASAGFLGVVLSSHAMGFLADTWGRATTLRYALCISSVCSIVSAFSVNIWMLI 141
            .|:..:.:.:|:|....:||:::.:...|.:||..||...|..:|.::||.:..|:|.......:
Frog   182 KDMCLSDSNKGMLGLIVYLGMMVGAFLWGGMADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFL 246

  Fly   142 VFRFLTGFFISGGQACVFSLCGEFHGTGSRIRHVTLLSGFLCMAMIFAPAMAIGILPLRIETIVL 206
            ..|.|:|..|.|....|||...||.....|..|::.|..|..:..|:|.|||..|:|....:..:
Frog   247 FCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFQM 311

  Fly   207 G--MHFSSWRVLLLANVSIPLLALVGISALPETPKYLLVQGRGDESLEVLRSIFANN---SGRDP 266
            |  ..|.||||.:|......:.|:..::.:||:|::.|..|:.||:..||:.:...|   .|...
Frog   312 GSAYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPE 376

  Fly   267 SEYPVK------------EVALESGGVSLSDVHGFLDAVRLVW---HQTVPLFYRARLWHTLNIC 316
            ..:.|.            |:..::|.:....:...|:..:.||   ||.....|| |:  ||.:.
Frog   377 RVFSVTQIKTIKQDDELVEIQSDTGALHRRWMIKLLNLSQEVWANFHQCFAPEYR-RI--TLMMM 438

  Fly   317 CIQFIIYFLAQGIFMWFPTILDELGT-----------------------------RNGE------ 346
            .:.|.:.|...|:.:|||.::..|..                             |.||
Frog   439 AVWFTMSFSYYGLTVWFPDMIKHLQNIDYASRTKYFHNESVNNFNFNFTLENQVHRKGEYHNDKF 503

  Fly   347 --------------------------NTLL--CTVLQGFNINSSSED---------------EAS 368
                                      ||..  |:.::....|:...|               ...
Frog   504 IGLKLKSVIFEDSLFTDCYFEDITSSNTFFKNCSFIRTMFYNTDLFDYKFINSKFTNSTFLHSKE 568

  Fly   369 SCSVEVDTSTYQVMIIIAACFVVIY------LIFAYIIDYMGKKNLLMAWMVLTMICLVALHY-- 425
            .|.::.........:|....|:...      ::.|.::|.:|:..:|....|::.|....|.:
Frog   569 GCQLDFSDDINNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCISCFFLFFGN 633

  Fly   426 VEQFALVVIALTVVMAIGNCGGLVSTIAMEFYPTHINAMGMCFIMMVGRLGAVVGSNILGRLL-F 489
            .|...:.::.|...::|.:...| ..:.:|.||:........|:..:.:|.||:|.:|....: .
Frog   634 SESAMIALLCLFGGVSIASWNAL-DVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGV 697

  Fly   490 ASCDPIFWALLALVVLLCTLGYFLPEK 516
            |...||..|..||.|     |.||..|
Frog   698 AKAVPILLASAALAV-----GSFLALK 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15221	NP_001096957.1	2A0115	36..488	CDD:273327	119/557 (21%)
CG15221	NP_001096957.1	MFS	51..488	CDD:119392	114/542 (21%)
sv2a	XP_012825002.1	synapt_SV2	1..729	CDD:130366	136/612 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208328at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920