DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango10 and BTBD6

DIOPT Version :9

Sequence 1:	NP_001259461.1	Gene:	Tango10 / 32125	FlyBaseID:	FBgn0030330	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001374496.1	Gene:	BTBD6 / 90135	HGNCID:	19897	Length:	538	Species:	Homo sapiens

Alignment Length:	347	Identity:	86/347 - (24%)
Similarity:	136/347 - (39%)	Gaps:	69/347 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GGGGCGAGGGGAGAGPGGGPG---------GGAAAADLAGEAAGGAAGGDAAINNQANANGTS-- 90
            |....||...||.|.|...|.         ..|||||||...||.|.|..|...:..:|...:
Human    32 GARARGAASTGAEAAPAAPPAKMAAELYAPASAAAADLANSNAGAAVGRKAGPRSPPSAPAPAPP 96

  Fly    91 ----ESPAKGLNSSEDLDAKRRKCRETEEGQDEASTMIDANSVLNKIANLYAEQLMSDIVLLVD- 150
                ..|..|.|..|  ....|.||.|               :..:.|.::..:||:|:..:|.
Human    97 PPAPAPPTLGNNHQE--SPGWRCCRPT---------------LRERNALMFNNELMADVHFVVGP 144

  Fly   151 ---GKEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLYVGQIEVT 212
               .:..|||:.:|...|.||..|.    :.:.::...|:|......|.|...:||:|..:|::.
Human   145 PGATRTVPAHKYVLAVGSSVFYAMF----YGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLE 205

  Fly   213 LQTVMPMLALSDKYNIRDLIDLCVDYMNKHVAKAATSGYLVSWLQYTLSFTPTHNDLTETLKRFL 277
            ..||:..|..:.||.:..|...||:::...: :|..:..|:|  |..|...|   :||:.....:
Human   206 ADTVLATLYAAKKYIVPALAKACVNFLETSL-EAKNACVLLS--QSRLFEEP---ELTQRCWEVI 264

  Fly   278 KWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMEATGSGGFMELI 342
            ....||...|..|.|:|...|.:::.: :.:.|.|..:|:.:..|       .||...
Human   265 DAQAEMALRSEGFCEIDRQTLEIIVTR-EALNTKEAVVFEAVLNW-------AEAECK------- 314

  Fly   343 EQTVSHIRFGM-MTPRQLSHLL 363
                   |.|: :|||...|:|
Human   315 -------RQGLPITPRNKRHVL 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango10	NP_001259461.1	BTB	135..239	CDD:279045	28/107 (26%)
		BTB	144..242	CDD:197585	26/101 (26%)
		BACK	258..359	CDD:197943	22/101 (22%)
BTBD6	NP_001374496.1	BTB_POZ_BTBD6	128..236	CDD:349658	28/111 (25%)
		BACK_BTBD6	236..330	CDD:350600	28/122 (23%)
		PHR	392..537	CDD:400388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810