DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango10 and Btbd17

DIOPT Version :9

Sequence 1:	NP_001259461.1	Gene:	Tango10 / 32125	FlyBaseID:	FBgn0030330	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_017170266.1	Gene:	Btbd17 / 72014	MGIID:	1919264	Length:	485	Species:	Mus musculus

Alignment Length:	549	Identity:	138/549 - (25%)
Similarity:	228/549 - (41%)	Gaps:	89/549 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PGGGPGGGAAAADLAGEAAGGAAGGDAAINNQANANGTSESPAKGLNSSEDLDAKRRKCRETEEG 116
            |..||     :|.|||....||..|.|           ...||              ..:..:.|
Mouse     8 PPVGP-----SAVLAGSTRPGALSGSA-----------MSLPA--------------AAQRADVG 42

  Fly   117 QDEASTMID-ANSVLNKIANLYAEQLMSDIVLLVDG------KEFPAHRVILCASSDVFQVMLMN 174
            .:.|.|.|: ::.:|.::.:|..:...||::|.|..      :.|..||::|...|::|:.:|.|
Mouse    43 GEAAGTAINHSHMLLQRLQDLLRQGNASDVILRVQAVGTDEVRAFHTHRLLLGLHSELFRELLSN 107

  Fly   175 PEWNECSKHVIELHEEACCSAVFPQFIKYLYVGQIEVTLQTVMPMLALSDKYNIRDLIDLCVDYM 239
                   :..:.|.|...|:|||.:||:|||.|::.|.|...:|:..|:.||.:..|.....|||
Mouse   108 -------QSEVMLRESRDCAAVFDKFIRYLYCGELTVLLAQAIPLHRLATKYRVASLQRGVADYM 165

  Fly   240 NKHVAKAATSGYLVSWLQYTLSFTPTHND-LTETLKRFLKWNLEMVAESRDFVEMDPAILILLLQ 303
            ..|:|...  |..|.|..|.:|   |.:: |.|:..:||.|||..||.|.::..:.|.:|..|||
Mouse   166 RAHLAGGV--GPAVGWYHYAVS---TGDEALRESCLQFLAWNLSAVAGSAEWGAVSPELLAQLLQ 225

  Fly   304 QNDLVVTSEYKLFDILQTWLLHRREQMEATGSGGFMELIEQTVSHIRFGMMTPRQLSHL-LMDPL 367
            ::|||:..|.:||..|:.||...|..         ..:.|:.:..||:.|:.|.||..| .....
Mouse   226 RSDLVLQDELELFHALEAWLGRARPP---------PTVAERALRAIRYPMIPPAQLFQLQARSAA 281

  Fly   368 VEYHKEFLVERIAIGMSYQSGHEDRVREVRATESGKLQFTPRLYWNDTWSVDIDVHNFTAIEDYK 432
            :..|...:.:.:.  .:||......:...:........|.||.|....|.....::|....:...
Mouse   282 LARHGPAVADLLL--QAYQFHAASPLHYAKFFHVNGSAFLPRNYLAPAWGAPWVINNPARDDRST 344

  Fly   433 NYVTCFFSQRHIAETEEDDPCMTWEIEFFPRGVRYNKAKMVW----GEDVPGCSLNTVRLRVTCK 493
            ::.|......|.|...     :||.:.|.||.:..: .:.|:    |..:|.......|.|:...
Mouse   345 SFQTQLGPSGHDAGRR-----ITWNVLFSPRWLPVS-LRPVYADAAGTALPAARPEDGRPRLVVT 403

  Fly   494 HQNIGEERFKIA---VLIVGMQNQIMHIRTVVERTEYFSDTSRVVNLDNLLPYEELE-HTSLYLS 554
            ..:.|.:...::   .::||.::|   .|.:|.....|..:|.  ...:.|.:.:|: ..|.||
Mouse   404 PASSGGDAAGVSFQKTVLVGARHQ---GRLLVRHAYSFHQSSE--EAGDFLAHADLQRRNSEYL- 462

  Fly   555 PHLTGTARNTLTLHVVITPMGSHTCRDTP 583
                  ..|.|.||:::.|: .||...||
Mouse   463 ------VENALHLHLIVKPV-YHTLIRTP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango10	NP_001259461.1	BTB	135..239	CDD:279045	33/109 (30%)
		BTB	144..242	CDD:197585	33/103 (32%)
		BACK	258..359	CDD:197943	33/101 (33%)
Btbd17	XP_017170266.1	BTB_POZ	67..165	CDD:365784	32/104 (31%)
Btbd17	XP_017170266.1	BACK_BTBD17	173..245	CDD:350568	28/76 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844352
Domainoid	1	1.000	53	1.000	Domainoid score	I11296
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H46324
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4720
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174057at2759
OrthoFinder	1	1.000	-	-		FOG0005455
OrthoInspector	1	1.000	-	-		oto94900
orthoMCL	1	0.900	-	-		OOG6_108144
Panther	1	1.100	-	-	O	PTHR24410
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5115
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.830