DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango10 and lgals3bp.3

DIOPT Version :9

Sequence 1:	NP_001259461.1	Gene:	Tango10 / 32125	FlyBaseID:	FBgn0030330	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001035130.1	Gene:	lgals3bp.3 / 677742	ZFINID:	ZDB-GENE-060331-57	Length:	567	Species:	Danio rerio

Alignment Length:	529	Identity:	113/529 - (21%)
Similarity:	203/529 - (38%)	Gaps:	122/529 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GGPGG-GAAAADLAGEAAGGAAGGDAAINNQANANGTSESPAKGLNSSEDLDAKRRKCRETEEGQ 117
            |.||. ..|:....||.:|.....|  :|.:.:.:..||...||...::        |..    |
Zfish    75 GFPGAVSVASGGQYGEGSGPIWLDD--MNCKGSESILSECCFKGWGVND--------CTH----Q 125

  Fly   118 DEASTMIDANSVLNKIANLYAEQ---LMSDIVLLVDGKE------------------FPAHRVIL 161
            ::|..:.|..:....|..:..:.   |..|:.||.|.::                  ...|||||
Zfish   126 EDAGVVCDTGTNATNIRQISVDNSLGLSDDLGLLFDSEDGCDFIIAVQDLGEEAELTLCVHRVIL 190

  Fly   162 CASSDVFQVMLMNPEWN--------------ECSKHVIELHEEACCSAVFPQFIKYLYVGQIEVT 212
                      :|.||.|              .|..||..|             |:|||..||:|:
Zfish   191 ----------MMYPELNITNDTRNLTVDVSQTCQSHVSAL-------------IRYLYTRQIDVS 232

  Fly   213 LQTVMPMLALSDKYNIRDLIDLCVDYMNKHVAKAATSGYLVSWLQYTLSFTPTHNDLT--ETLKR 275
            ..:...:..|:..:.::.|::.........:.:..|....||..:|.|    ...||.  |.:.:
Zfish   233 ATSAQCLYQLAFIFGVQRLMEDVGRVFTALIPEDNTFQTPVSMYEYGL----RTGDLVLQENVLQ 293

  Fly   276 FLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMEATGSGGFME 340
            :|.||.|.:..|..:..:...::..|||::||:|..|..|.:.|:.|:..:.:|:.:......:
Zfish   294 YLSWNCEFLISSPVWSTVSFEMMDALLQRSDLIVKDEAVLLEALERWIQDKGDQISSDKQASLL- 357

  Fly   341 LIEQTVSHIRFGMMTPRQLSHLLM--DPLVEYHKEFLVERIAIGMSYQSGHEDRVREVRATESGK 403
                  |||||.::...:|..:..  ..|.:.:::..:..:..|..:.:....::|  ...::..
Zfish   358 ------SHIRFLLIPVDKLYDIQFSSSALYQNNEKLYLTGLLRGFEFNALPFSKIR--NQIDNAS 414

  Fly   404 LQFTPRLYWNDTWSVDIDVHNFTAIEDYKNY--------VTCFFSQRHIAETEEDDPCMTWEIEF 460
            .::.||:|..|.|||.|  ::.|....|.||        :..||:..|.:...:|.. :.|:.:.
Zfish   415 SEYLPRIYTGDEWSVFI--NDTTVSSPYYNYNYYGQSNRIQTFFTSAHPSALYKDQK-VQWQAQV 476

  Fly   461 F-------PRGVRYNKAKMV--WGEDVPGCSLNTV----RLRVTCKHQN----IGEERFKIAVL- 507
            |       ..||..|...:.  :|........|.:    ||.:|||:||    :.|.:..:||:
Zfish   477 FLTLQECSNYGVSCNTLPVARFYGYSNQYSYSNIISYNNRLILTCKNQNNVFHVQEFKNDVAVIP 541

  Fly   508 ---IVGMQN 513
               .:|:.|
Zfish   542 TNSSMGLPN 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango10	NP_001259461.1	BTB	135..239	CDD:279045	27/138 (20%)
		BTB	144..242	CDD:197585	26/129 (20%)
		BACK	258..359	CDD:197943	26/102 (25%)
lgals3bp.3	NP_001035130.1	SR	34..132	CDD:214555	16/70 (23%)
		SRCR	38..132	CDD:278931	16/70 (23%)
		BTB	167..257	CDD:197585	22/112 (20%)
		BACK	273..370	CDD:197943	28/107 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589251
Domainoid	1	1.000	51	1.000	Domainoid score	I11558
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174057at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24410
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950