DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango10 and btbd17

DIOPT Version :9

Sequence 1:	NP_001259461.1	Gene:	Tango10 / 32125	FlyBaseID:	FBgn0030330	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001008447.2	Gene:	btbd17 / 493324	XenbaseID:	XB-GENE-5958973	Length:	480	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	127/506 - (25%)
Similarity:	231/506 - (45%)	Gaps:	85/506 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 RRKC------------RETEEGQDEASTMIDANSVL-NKIANLYAEQLMSDIVLLV------DGK 152
            ||.|            ::::.|.|.::.:|:.:.:| .::.:|:.:...:|.:|.:      :.|
Frog    14 RRFCVVPLLLVLVEAAQKSDLGGDASAALINHSPMLIQRLQDLFHKGNSTDTILRIRTANSDEVK 78

  Fly   153 EFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLYVGQIEVTLQTVM 217
            ....|:::|...||:|..:|:|       :..:.|.|.|.|:|:|.:||:|.|.|:|.|.|...:
Frog    79 VIHVHQLLLTLQSDIFDGLLLN-------QSEVTLQEPAECAALFEKFIRYFYCGEISVNLNQAI 136

  Fly   218 PMLALSDKYNIRDLIDLCVDYMNKHVAKAATSGYLVSWLQYTLSFTPTHNDLTETLKRFLKWNLE 282
            |:..|::||::..|.....:||..|.:..:..|::|||..|.|.....  :|.|:..:||.|||.
Frog   137 PLHRLANKYHMTALQRGVTEYMKTHFSSESAQGHVVSWYHYALRMGDI--NLQESCLKFLAWNLS 199

  Fly   283 MVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMEATGSGGFMELIEQTVS 347
            .:..|.::|.:...:::.|||::|||:.||.:||..::.|:...:..         .::||:.:.
Frog   200 TIMSSNEWVTVSDKLMVSLLQRSDLVLQSELELFSAVEEWISKNKPD---------AQVIEKVLR 255

  Fly   348 HIRFGMMTPRQLSHLLMDP--LVEYHKEFLVERIAIGMSYQSG---HEDRVREVRATESGKLQFT 407
            .||:.|::|.||..:..:.  |..||.. :.:.:.....:.|.   |..:..:|..:     .|.
Frog   256 SIRYPMISPSQLFQIQKESAVLASYHNS-VQDLMFQAFQFHSASPLHFAKYFDVNCS-----MFV 314

  Fly   408 PRLYWNDTWSVDIDVHNFTAIEDYKNYVTCFFSQRHIAETEEDDPCMTWEIEFFPRGVRYNKAKM 472
            ||.|.:.:|.....::|....:....:.|......|  :|.:.   |||...|.||.:..: .:.
Frog   315 PRNYLSPSWGSQWIINNPARDDRSLTFQTQLGPSNH--DTSKK---MTWNALFSPRWLPVS-LRP 373

  Fly   473 VWGEDVPGCSLNT------VRLRVT--CKHQNIGEERFKIAVLIVGMQNQ-----IMHIRTVVER 524
            |:.|.:|..|.:.      .||.||  ....:.....|:..|| ||::.|     :.|:..|.:.
Frog   374 VYSESIPSSSQSNRLEEGKPRLVVTSAMSGMDFAGVTFQKTVL-VGVKRQQSKVFVKHVYNVHQS 437

  Fly   525 T-EYFSDTSRVVNLDNLLPYEELEHTSLYLSPHLTGTARNTLTLHVVITPM 574
            | |.|         |.||..:..:.||.||       ..|:|.||::|.|:
Frog   438 TDEVF---------DFLLQADLQKRTSEYL-------IDNSLHLHIIIKPI 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango10	NP_001259461.1	BTB	135..239	CDD:279045	30/109 (28%)
		BTB	144..242	CDD:197585	31/103 (30%)
		BACK	258..359	CDD:197943	28/100 (28%)
btbd17	NP_001008447.2	BTB	53..159	CDD:295341	31/112 (28%)
		BTB	78..161	CDD:197585	29/89 (33%)
		BACK	171..269	CDD:285009	33/108 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10844
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H46324
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4414
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174057at2759
OrthoFinder	1	1.000	-	-		FOG0005455
OrthoInspector	1	1.000	-	-		otm49290
Panther	1	1.100	-	-	O	PTHR24410
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5115
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190