DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango10 and BTBD17

DIOPT Version :9

Sequence 1:	NP_001259461.1	Gene:	Tango10 / 32125	FlyBaseID:	FBgn0030330	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_011523093.1	Gene:	BTBD17 / 388419	HGNCID:	33758	Length:	479	Species:	Homo sapiens

Alignment Length:	513	Identity:	137/513 - (26%)
Similarity:	218/513 - (42%)	Gaps:	76/513 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 AKRRKCRETEEGQDE-----------------ASTMID-ANSVLNKIANLYAEQLMSDIVLLVDG 151
            |.|..|||.|..|.|                 |.|.|: :.:||.::..|..:...||:||.|..
Human     8 APRLFCREPETFQGEARLALLGAQRADVGGEAAGTSINHSQAVLQRLQELLRQGNASDVVLRVQA 72

  Fly   152 ------KEFPAHRVILCASSDVFQVMLMNPEWNECSKHVIELHEEACCSAVFPQFIKYLYVGQIE 210
                  :.|.|||::|...|::|..:|.|.     |:.|  |.|...|:|||.:||:|||.|::.
Human    73 AGTDEVRVFHAHRLLLGLHSELFLELLSNQ-----SEAV--LQEPQDCAAVFDKFIRYLYCGELT 130

  Fly   211 VTLQTVMPMLALSDKYNIRDLIDLCVDYMNKHVAKAATSGYLVSWLQYTLSFTPTHND-LTETLK 274
            |.|...:|:..|:.||.:..|.....|||..|:|..|  |..|.|..|.:.   |.:: |.|:..
Human   131 VLLTQAIPLHRLATKYGVSSLQRGVADYMRAHLAGGA--GPAVGWYHYAVG---TGDEALRESCL 190

  Fly   275 RFLKWNLEMVAESRDFVEMDPAILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMEATGSGGFM 339
            :||.|||..||.|.::..:.|.:|..|||::|||:..|.:||..|:.||...|..         .
Human   191 QFLAWNLSAVAASTEWGAVSPELLWQLLQRSDLVLQDELELFHALEAWLGRARPP---------P 246

  Fly   340 ELIEQTVSHIRFGMMTPRQLSHL-LMDPLVEYHKEFLVERIAIGMSYQSGHEDRVREVRATESGK 403
            .:.|:.:..||:.|:.|.||..| .....:..|...:.:.:.  .:||......:...:..:...
Human   247 AVAERALRAIRYPMIPPAQLFQLQARSAALARHGPAVADLLL--QAYQFHAASPLHYAKFFDVNG 309

  Fly   404 LQFTPRLYWNDTWSVDIDVHNFTAIEDYKNYVTCFFSQRHIAETEEDDPCMTWEIEFFPRGVRYN 468
            ..|.||.|....|.....::|....:...::.|......|.|...     :||.:.|.||.:..:
Human   310 SAFLPRNYLAPAWGAPWVINNPARDDRSTSFQTQLGPSGHDAGRR-----VTWNVLFSPRWLPVS 369

  Fly   469 KAKMVW----GEDVPGCSLNTVRLRVTCKHQNIGEERFKIA---VLIVGMQNQIMHIRTVVERTE 526
             .:.|:    |..:|.......|.|:.....:.|.:...::   .::||.:.|   .|.:|....
Human   370 -LRPVYADAAGTALPAARPEDGRPRLVVTPASSGGDAAGVSFQKTVLVGARQQ---GRLLVRHAY 430

  Fly   527 YFSDTSRVVNLDNLLPYEELE-HTSLYLSPHLTGTARNTLTLHVVITPMGSHTCRDTP 583
            .|..:|.  ...:.|.:.:|: ..|.||       ..|.|.||:::.|: .||...||
Human   431 SFHQSSE--EAGDFLAHADLQRRNSEYL-------VENALHLHLIVKPV-YHTLIRTP 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango10	NP_001259461.1	BTB	135..239	CDD:279045	37/109 (34%)
		BTB	144..242	CDD:197585	37/103 (36%)
		BACK	258..359	CDD:197943	32/101 (32%)
BTBD17	XP_011523093.1	BTB	54..159	CDD:279045	37/111 (33%)
		BTB	65..163	CDD:197585	37/104 (36%)
		BACK	170..268	CDD:197943	36/109 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154107
Domainoid	1	1.000	53	1.000	Domainoid score	I11368
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H46324
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4763
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174057at2759
OrthoFinder	1	1.000	-	-		FOG0005455
OrthoInspector	1	1.000	-	-		oto91322
orthoMCL	1	0.900	-	-		OOG6_108144
Panther	1	1.100	-	-	O	PTHR24410
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5115
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.830