DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango10 and Klhl25

DIOPT Version :9

Sequence 1:	NP_001259461.1	Gene:	Tango10 / 32125	FlyBaseID:	FBgn0030330	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001116252.1	Gene:	Klhl25 / 207952	MGIID:	2668031	Length:	589	Species:	Mus musculus

Alignment Length:	335	Identity:	67/335 - (20%)
Similarity:	125/335 - (37%)	Gaps:	71/335 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 ETEEGQDEASTM--------IDANSVLNKIANLYAEQLMSDIVLLVDGKEFPAHRVILCASSDVF 168
            ||.:.:....:|        ...:.||..:..|....:.:|:.|....:.||.||.:|.|||..|
Mouse     7 ETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYF 71

  Fly   169 QVML---MNPEWNECSKHVIELHEEACCSAVFPQFIKYLYVGQIEVTLQTVMPMLALSDKYNIRD 230
            :.|.   :....::.......||.|     |....:.:.|..:|.:..:....:|...|.....|
Mouse    72 EAMFSHGLRESRDDTVNFQDNLHPE-----VLELLLDFAYSSRIVINEENAESLLEAGDMLQFHD 131

  Fly   231 LIDLCVDYMNKHVAKAATSGYLVSWLQYTLSFTPTHNDLTETLKRFLKWNLEMVAESRDFVEMDP 295
            :.|...:::.|:::.:...|.:|      ||.......|.|...|....:.|.|.:|.||..:..
Mouse   132 VRDAAAEFLEKNLSPSNCLGMMV------LSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSR 190

  Fly   296 AILILLLQQNDLVVTSEYKLFDILQTWLLHRREQMEA---------------------TGSGGFM 339
            ..|:.|:.:::|....|..:|:.:..|:.|..||.:|                     ..||..:
Mouse   191 DTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKAHLPLLLRNVRLALLPSDCLKNAVSGEAL 255

  Fly   340 ELIEQ-------------TVSHIRFGMMT-----PRQLSHLLMDPLVEYHKEFLVERIAIGMSYQ 386
            .:.::             |...:..|::|     ||:..|.|   |:...:.|:.::|     ||
Mouse   256 LMADECTKLILDEAFRCKTKILLNDGVVTSPFARPRKAGHTL---LILGGQTFMCDKI-----YQ 312

  Fly   387 SGHEDRVREV 396
            ..|  :.:|:
Mouse   313 VDH--KAKEI 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango10	NP_001259461.1	BTB	135..239	CDD:279045	23/106 (22%)
		BTB	144..242	CDD:197585	22/100 (22%)
		BACK	258..359	CDD:197943	27/139 (19%)
Klhl25	NP_001116252.1	BTB_POZ_KLHL25	24..151	CDD:349563	26/131 (20%)
		PHA03098	39..566	CDD:222983	62/303 (20%)
		Kelch 1	296..340		8/35 (23%)
		KELCH repeat	330..374	CDD:276965
		Kelch 2	341..388
		KELCH repeat	378..431	CDD:276965
		Kelch 3	389..444
		KELCH repeat	434..480	CDD:276965
		Kelch 4	446..492
		KELCH repeat	482..524	CDD:276965
		Kelch 5	493..538
		KELCH repeat	528..565	CDD:276965
		Kelch 6	539..585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910