DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and Pdia5

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_082571.1	Gene:	Pdia5 / 72599	MGIID:	1919849	Length:	517	Species:	Mus musculus

Alignment Length:	416	Identity:	104/416 - (25%)
Similarity:	177/416 - (42%)	Gaps:	66/416 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RSILSVAVCGLLLSPLLPITRASQEEDTGKQDKQFTVELDPE-TFDTAIAGGN--VFVKFFAPWC 65
            |::...::...|..|..|   ...|||.|.:|   .|.:|.| .|...:....  :.:.|:||||
Mouse   122 RAVTLKSIVAFLKDPKGP---PLWEEDPGAKD---VVHIDSEKDFRRLLKREEKPLLMMFYAPWC 180

  Fly    66 GHCKRIQPLWEQLAEIMNVDNPKVIIAKVDC--TKHQGLCATHQVTGYPTLRLFKLGE------- 121
            ..||||.|.:::.|..:   ...:::|.::.  ::.:.:...:.|.||||:..|:.|.
Mouse   181 SMCKRIMPHFQKAATQV---RGHIVLAGMNVYPSEFENIKEEYNVRGYPTICYFEKGRFLFPYEN 242

  Fly   122 -----EESVKFKGTRDLPAITDFINKELSAPAEADLGEVKREQVENLNIGKVVDLTEDTFAKHVS 181
                 |:.|::. ...||.     ..::.....||.|            |.|..||::.|.:.|.
Mouse   243 YGSTAEDIVEWL-KNPLPP-----QPQVPETPWADEG------------GSVYHLTDEDFDQFVK 289

  Fly   182 T-GNHFVKFFAPWCSHCQRLAPTWEDLAKEL--IKEPTVTISKIDCTQFRSICQDFEVKGYPTLL 243
            . .:..|.|.||||.||:::.|.:|..|:.|  ..|.:..::.:|.|...::...|.:..:|||.
Mouse   290 EHSSVLVMFHAPWCGHCKKMKPEFESAAEVLHGDAESSGVLAAVDATVNEALAGRFHISAFPTLK 354

  Fly   244 WIEDGKKIEKYSGARDLSTLKTYVEKMVGVPLEKTAGEAGDEKVVIEEVAGEEDAAKKLTPQQLT 308
            :.::|::    .....|.|.|.::|.|           ...|.....|...||.....|   .|.
Mouse   355 YFKNGEQ----QAVPALRTKKKFIEWM-----------QNPEAPPPPEPTWEEQQTSVL---HLV 401

  Fly   309 GEDEFDQAIAEGVAFIKFYAPWCGHCQKLQPTWEQLATETHQAQSSVKIAKVDCTAPENKQVCID 373
            |::..|....:....:.||||||.||:|:.|.:...| :..:....:..|.|||...:|:.:|..
Mouse   402 GDNFRDTLKKKKHTLVMFYAPWCPHCKKVIPHFTATA-DAFKEDRKIACAAVDCVKDKNQDLCQQ 465

  Fly   374 QQVEGYPTLFLYKNGQRQNEYEGSRS 399
            :.|:.|||...|..|:...:||..|:
Mouse   466 EAVKAYPTFHYYHYGKLVEKYESDRT 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	27/118 (23%)
		ER_PDI_fam	39..409	CDD:273457	95/381 (25%)
		PDI_a_ERp46	167..267	CDD:239303	28/102 (27%)
		PDI_a_ERp46	303..407	CDD:239303	29/97 (30%)
Pdia5	NP_082571.1	PDI_b_PDIR_N	26..137	CDD:239365	2/14 (14%)
		PTZ00102	122..517	CDD:240266	104/416 (25%)
		PDI_a_PDIR	150..254	CDD:239295	26/109 (24%)
		PDI_a_PDIR	275..377	CDD:239295	29/105 (28%)
		PDI_a_PDIR	396..499	CDD:239295	30/100 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	514..517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D522268at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820