DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and Txndc16

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001297463.1	Gene:	Txndc16 / 70561	MGIID:	1917811	Length:	820	Species:	Mus musculus

Alignment Length:	259	Identity:	50/259 - (19%)
Similarity:	105/259 - (40%)	Gaps:	49/259 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 EIMNVDNPKVIIAKVDCTKHQGLCATHQVTGYPTLRLFKLGEEESVKFKGTRDLPAITDFINKEL 144
            |.:.:::.::||:.|....|                :.::.|:|....:|            .:|
Mouse   334 EFLVLNDVELIISHVKNNMH----------------IEEIQEDEGEDMEG------------PDL 370

  Fly   145 SAPAEADLGEVKREQVENLNIGKVVDLTEDTFAKHVSTGNHFVKFFAPWCSHCQRLAPTWEDLAK 209
            :...:...|.|.|::.:.|.:...|:|||:||...|.|.:..|.|:|.|.:.......::.|:|.
Mouse   371 AVEDDEVAGTVYRDRKKPLPLELSVELTEETFNTTVMTSDSIVLFYATWHAVSMAFLQSYIDVAI 435

  Fly   210 ELIKEPTVTISKIDCTQFRSICQDFEVKGYPTLLWIEDGKKIEKYSGARDLSTLKTYVE-KMVGV 273
            :|....|:.:::|:|..:..||....|..:|.:...::|:....|:|......|..::: ..:..
Mouse   436 KLKGRSTILLTRINCADWSDICTKQNVTAFPVVKLYKEGESPVSYAGMLATKDLLKFIQLNKISC 500

  Fly   274 PLEKTAGEAGDEKVVIEEVAGEEDAAKKLTPQQLTGEDEFDQAIAEGVAFIKFYAPWCGHCQKL 337
            |:               .:|..::|.|     .|.||...|...:..|:.:..::|.....::|
Mouse   501 PV---------------NIASIQEAEK-----YLRGELYKDLPSSASVSVLGLFSPAMASAKEL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	8/59 (14%)
		ER_PDI_fam	39..409	CDD:273457	50/259 (19%)
		PDI_a_ERp46	167..267	CDD:239303	26/99 (26%)
		PDI_a_ERp46	303..407	CDD:239303	7/35 (20%)
Txndc16	NP_001297463.1	ER_PDI_fam	65..493	CDD:273457	39/186 (21%)
		PDI_a_family	395..493	CDD:239259	26/97 (27%)
		Thioredoxin_6	534..722	CDD:372755	2/11 (18%)
		Mediates endoplasmic reticulum retention. /evidence=ECO:0000250\|UniProtKB:Q9P2K2	817..820
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900