DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and Erp27

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_081259.1	Gene:	Erp27 / 69187	MGIID:	1916437	Length:	272	Species:	Mus musculus

Alignment Length:	319	Identity:	56/319 - (17%)
Similarity:	111/319 - (34%)	Gaps:	100/319 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTRS---ILS-VAVCGLLLSPLLPITRASQEEDT-GKQDKQFTVELD--PETFDTAIAGGNVFVK 59
            :|||   ||| |.|||     |:|...|..||.| |....|..:.|.  |.|.:...|.....:.
Mouse     3 ITRSRCLILSFVLVCG-----LVPEVTADVEEATDGLSTTQEPIWLTDVPATVELIAAAEVAVIG 62

  Fly    60 FFAPWCGHCKRIQPLWEQLAEIMNVDNPKVIIAKVDCTKHQGLCATHQVTGYPTLRLFKLGEEES 124
            ||          |.|...:..:......:........:.|..:...:.||. .::.||:|.:::.
Mouse    63 FF----------QDLEIPIVSVFRSMARQFQDVSFGISNHSEVLTHYNVTS-NSICLFRLVDDQQ 116

  Fly   125 VKFKGTRDLPAITDFINKELSAPAEADLGEVKREQVENLNIGKVVDLTEDTFAKHVSTGN-HFVK 188
            :                            .:..|.:|||:..|:        ::.:...| |:|.
Mouse   117 L----------------------------HLNAEDIENLDAAKL--------SRFIHVNNLHWVT 145

  Fly   189 FFAPWC----------SH----CQRLAPTWEDLAKELIKEPTVTISKIDCTQFRSICQDFEVKGY 239
            .::|..          :|    .::.:|.:|:..:                ::|...:.|:  |.
Mouse   146 EYSPMIAAGLFNTMVQTHLLLMMKKTSPEYEESMR----------------RYREAAKLFQ--GQ 192

  Fly   240 PTLLWIEDGKKIEKYSGARDLSTLKTYVEKMVGVPLEKTAGEAGD----EKVVIEEVAG 294
            ...:.::.||:    ...:.:|..|....::..:.:.::..:..|    .:|.:|:|.|
Mouse   193 ILFVLVDSGKR----ENGKVMSYFKLKESQLPALAIYESVDDKWDTLPIAEVTVEKVRG 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	14/103 (14%)
		ER_PDI_fam	39..409	CDD:273457	38/277 (14%)
		PDI_a_ERp46	167..267	CDD:239303	15/114 (13%)
		PDI_a_ERp46	303..407	CDD:239303
Erp27	NP_081259.1	Thioredoxin_6	64..250	CDD:372755	33/253 (13%)
		PDIA3-binding site. /evidence=ECO:0000250\|UniProtKB:Q96DN0	230..233		0/2 (0%)
		Prevents secretion from ER. /evidence=ECO:0000250\|UniProtKB:Q96DN0	269..272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810