DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and TMX3

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_061895.3	Gene:	TMX3 / 54495	HGNCID:	24718	Length:	454	Species:	Homo sapiens

Alignment Length:	275	Identity:	71/275 - (25%)
Similarity:	124/275 - (45%)	Gaps:	42/275 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KQFTVELDPETFDTAIAGGNVFVKFFAPWCGHCKRIQPLWEQLA-EIMNVDNPKVIIAKVDCTKH 99
            |.|..:|| |:|..........|.|:||||||||:::|:|.::. |:.::.:| |.:.|:|.|.:
Human    25 KGFVEDLD-ESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSP-VKVGKMDATSY 87

  Fly   100 QGLCATHQVTGYPTLRLFKLGEEESVKFKGTRDLPAITDFINKELSA-----PAEADLGEV-KRE 158
            ..:.:...|.||||::|.|  .:.:..::|.|....|.:|.::...|     |::.....: ||.
Human    88 SSIASEFGVRGYPTIKLLK--GDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRH 150

  Fly   159 QVENLNIGKVVDLTEDTFAKHVSTGNHFVKFFAPWCSHCQRLAPTWEDLAKELIKEPTVTISKID 223
            :|..:.:|....|.|    |::...:..: .:..:.|..:.:.|.:..| ||:   |.|.:.| |
Human   151 RVFFVYVGGESPLKE----KYIDAASELI-VYTYFFSASEEVVPEYVTL-KEM---PAVLVFK-D 205

  Fly   224 CTQFRSICQDFEVKGYPTLLWIE----------DGKKIEKYSGARDLSTLKTYVEKMVGVPLEKT 278
            .|.|  :..::|.....:  ||.          ||..:.:......|..|....||       .|
Human   206 ETYF--VYDEYEDGDLSS--WINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEK-------NT 259

  Fly   279 AGEAGDEKVVIEEVA 293
            :.|....|.:|:|||
Human   260 SVEHTRLKSIIQEVA 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	33/102 (32%)
		ER_PDI_fam	39..409	CDD:273457	69/272 (25%)
		PDI_a_ERp46	167..267	CDD:239303	21/109 (19%)
		PDI_a_ERp46	303..407	CDD:239303
TMX3	NP_061895.3	PDI_a_TMX3	27..130	CDD:239298	34/106 (32%)
		ER_PDI_fam	29..>346	CDD:273457	69/271 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..454
		Di-lysine motif	451..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910