DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and DNAJC10

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_061854.1	Gene:	DNAJC10 / 54431	HGNCID:	24637	Length:	793	Species:	Homo sapiens

Alignment Length:	369	Identity:	103/369 - (27%)
Similarity:	156/369 - (42%)	Gaps:	77/369 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VKFFAPWCGHCKRIQPLWEQLAEIMNVDNPKVIIAKVDCTKHQGLCATHQVTGYPTLRLFKLGEE 122
            |.||||||..|:.:.|   :|....|:...::....:|||.|:|||..:.:..|||..:|  .:.
Human   473 VDFFAPWCPPCRALLP---ELRRASNLLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVF--NQS 532

  Fly   123 ESVKFKGTRDLPAITDFINKELSAPAEADLGEVKREQVENLNIGKVVDLTEDTFAKHVSTGNH-- 185
            ...:::|......|.:||                    |:|....||.||..||.:.|:...|
Human   533 NIHEYEGHHSAEQILEFI--------------------EDLMNPSVVSLTPTTFNELVTQRKHNE 577

  Fly   186 --FVKFFAPWCSHCQRLAPTWEDLAKELIKEPTVTISKIDCTQFRSICQDFEVKGYPTLLWI--- 245
              .|.|::|||..||.|.|.|:.:|:.|  ...:.:..|||.|:.|.|....|:.||.:.:.
Human   578 VWMVDFYSPWCHPCQVLMPEWKRMARTL--TGLINVGSIDCQQYHSFCAQENVQRYPEIRFFPPK 640

  Fly   246 -EDGKKIEKYSG-ARDLSTLKTYVEKMVGVPLEKTAGEAGDEKVVIEEVAGEEDAAKKLTPQQLT 308
             ........|:| .||..:|:.:     |:..             :.:|:.:      ||||
Human   641 SNKAYHYHSYNGWNRDAYSLRIW-----GLGF-------------LPQVSTD------LTPQ--- 678

  Fly   309 GEDEFDQAIAEGVA--FIKFYAPWCGHCQKLQPTWEQLATETHQAQSSVKIAKVDCTAPENKQVC 371
               .|.:.:.:|..  .|.|||||||.||...|.:|.||   ...:..||..||||.|  ..|.|
Human   679 ---TFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLA---RMIKGKVKAGKVDCQA--YAQTC 735

  Fly   372 IDQQVEGYPTL--FLYKNGQR--QNEYEGSRSLPELQAYLKKFL 411
            ....:..|||:  :.|:..:|  |.|...:|....:.|.:.:.|
Human   736 QKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISEKL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	24/81 (30%)
		ER_PDI_fam	39..409	CDD:273457	102/365 (28%)
		PDI_a_ERp46	167..267	CDD:239303	34/108 (31%)
		PDI_a_ERp46	303..407	CDD:239303	37/109 (34%)
DNAJC10	NP_061854.1	DnaJ	34..>132	CDD:223560
		PDI_a_ERdj5_N	129..229	CDD:239301
		Trxb 1	235..350
		Trxb 2	348..463
		PDI_a_ERdj5_C	453..550	CDD:239302	24/81 (30%)
		PDI_a_ERdj5_C	556..663	CDD:239302	34/108 (31%)
		PDI_a_ERdj5_C	670..775	CDD:239302	39/121 (32%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	790..793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D522268at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820