DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and p4hb

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_998529.3	Gene:	p4hb / 406673	ZFINID:	ZDB-GENE-080610-1	Length:	509	Species:	Danio rerio

Alignment Length:	518	Identity:	122/518 - (23%)
Similarity:	195/518 - (37%)	Gaps:	175/518 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VCGLLLSPLLPITRASQEEDTGKQDKQFTVELDPETFDTAI-AGGNVFVKFFAPWCGHCKRIQPL 74
            ||.|   ..:.....::|||        .:.|....|:.|: |..||.|:|:||||||||.:.|.
Zfish     7 VCAL---AAMSAAEIAEEED--------VLVLKKSNFEEALKAHPNVLVEFYAPWCGHCKALAPE 60

  Fly    75 WEQLAEIMNVDNPKVIIAKVDCTKHQGLCATHQVTGYPTLRLFKLGEEESVK-FKGTRDLPAITD 138
            :.:.|.::..:...:.:||||.|:...|.....|.||||::.||.||:.:.| :...|....|..
Zfish    61 YSKAAGMLKAEGSDIRLAKVDATEESELAQEFGVRGYPTIKFFKGGEKGNPKEYSAGRQAEDIVS 125

  Fly   139 FINKELSAPAEADLGEVKR-------------------------------EQVENLNIG------ 166
            ::.|. :.||...|.:|.:                               |.|:::..|
Zfish   126 WLKKR-TGPAATTLNDVMQAESIIADNEVAVIGFFKDVESEDSKAFIKTAEAVDDIPFGITSDDS 189

  Fly   167 ---------------KVVDLTEDTFAKHVSTGN--HFVK------------------FFAPWCSH 196
                           |..|...:||...||..:  :|:|                  |.....||
Zfish   190 VFAKFEVAKDSVVLFKKFDEGRNTFDGEVSKESLLNFIKANQLPLVIEFTEQTAPKIFGGDIKSH 254

  Fly   197 CQRLAPTWEDLAKELIKEPTVTISKIDCTQFRSICQDFEVKGYPTLLWI----EDGKKIEKYSGA 257
            .....|   ..||:.       ..|:|  ||:...:.|  ||....::|    :|.::|.::.|
Zfish   255 ILMFVP---KAAKDF-------QDKMD--QFKKAAEGF--KGKILFIFIDSDVDDNQRILEFFG- 304

  Fly   258 RDLSTLKTYVEKMVGVPLEKTAGEAGDEKVVIEEVAGEEDAAK-KLTPQQLTGED--EFDQAIAE 319
                             |:|      :|..||..:..||:..| |....::|.|:  .|..:..|
Zfish   305 -----------------LKK------EECPVIRLITLEEEMTKYKPESSEITAENIISFCTSFVE 346

  Fly   320 GV-------------------------------------AFIKFYAPWCGHCQKLQPTWEQLATE 347
            |.                                     .|::|||||||||::|.|.|:||. |
Zfish   347 GTLKPHLMSQDIPEDWDKNPVKVLVGKNFEEVAFNPANNVFVEFYAPWCGHCKQLAPIWDQLG-E 410

  Fly   348 THQAQSSVKIAKVDCTAPENKQVCIDQQVEGYPTLFLYKNGQRQN--EYEGSRSLPELQAYLK 408
            ..:..:::.:||:|.||.|.:.|    :|..:|||..:..|..:.  :|.|.|:|.....:|:
Zfish   411 KFKDNANIVVAKMDSTANEIEAV----KVHSFPTLKFFPAGDERKVIDYNGERTLDGFTKFLE 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	36/103 (35%)
		ER_PDI_fam	39..409	CDD:273457	116/490 (24%)
		PDI_a_ERp46	167..267	CDD:239303	25/123 (20%)
		PDI_a_ERp46	303..407	CDD:239303	37/144 (26%)
p4hb	NP_998529.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910