DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and Dnajc10

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001099956.2	Gene:	Dnajc10 / 295690	RGDID:	1307813	Length:	793	Species:	Rattus norvegicus

Alignment Length:	386	Identity:	107/386 - (27%)
Similarity:	163/386 - (42%)	Gaps:	92/386 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VKFFAPWCGHCKRIQPLWEQLAEIMNVDNPKVIIAKVDCTKHQGLCATHQVTGYPTLRLFKLGEE 122
            |.||||||..|:.:.|   :|.:...:...::.:..:|||.|:|||..:.:..|||..:|   .:
  Rat   473 VDFFAPWCPPCRALLP---ELRKASTLLYGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVF---NQ 531

  Fly   123 ESV-KFKGTRDLPAITDFINKELSAPAEADLGEVKREQVENLNIGKVVDLTEDTFAKHVSTGNH- 185
            .|| :::|......|.:||                    |:|....||.||..||.:.|....|
  Rat   532 SSVHEYEGHHSAEQILEFI--------------------EDLRNPSVVSLTPTTFNELVKQRKHD 576

  Fly   186 ---FVKFFAPWCSHCQRLAPTWEDLAKELIKEPTVTISKIDCTQFRSICQDFEVKGYPTLLWIED 247
               .|.|::|||..||.|.|.|:.:|:.|  ...:.:..:||.|:.|.|....|:.||.:.:...
  Rat   577 EVWMVDFYSPWCHPCQVLMPEWKRMARTL--TGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQ 639

  Fly   248 ----GKKIEKYSG-ARDLSTLKTYVEKMVGVPLEKTAGEAGDEKVVIEEVAGEEDAAKKLTPQQL 307
                ..:...|:| .||..:|:::  .:..:|                      .|:..||||
  Rat   640 KSSRAYQYHSYNGWNRDAYSLRSW--GLGFLP----------------------QASIDLTPQ-- 678

  Fly   308 TGEDEFDQAIAEGVA--FIKFYAPWCGHCQKLQPTWEQLATETHQAQSSVKIAKVDCTAPENKQV 370
                .|::.:.:|..  .|.|||||||.||...|.:|.||   ...:..||..||||.|  ..|.
  Rat   679 ----TFNEKVLQGKTHWVIDFYAPWCGPCQNFAPEFELLA---RMIKGKVKAGKVDCQA--YPQT 734

  Fly   371 CIDQQVEGYPT--LFLYKNGQRQ--NEYEGSR-----------SLPELQAYLKKFLGHDEL 416
            |....:..||:  |:||:..::.  .|...||           .|...|:.:|:  ..|||
  Rat   735 CQKAGIRAYPSVKLYLYERAKKSIWEEQINSRDAKTIAALIYGKLETFQSQVKR--NKDEL 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	25/82 (30%)
		ER_PDI_fam	39..409	CDD:273457	103/377 (27%)
		PDI_a_ERp46	167..267	CDD:239303	33/108 (31%)
		PDI_a_ERp46	303..407	CDD:239303	38/120 (32%)
Dnajc10	NP_001099956.2	DnaJ	34..>132	CDD:223560
		DnaJ	35..97	CDD:278647
		PDI_a_ERdj5_N	129..229	CDD:239301
		ER_PDI_fam	130..551	CDD:273457	27/103 (26%)
		Trxb 1	235..350
		Trxb 2	348..463
		PDI_a_ERdj5_C	453..550	CDD:239302	25/82 (30%)
		PDI_a_ERdj5_C	556..663	CDD:239302	33/108 (31%)
		PDI_a_ERdj5_C	670..775	CDD:239302	38/115 (33%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	790..793		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D522268at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820