DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and PDIA3

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_005304.3	Gene:	PDIA3 / 2923	HGNCID:	4606	Length:	505	Species:	Homo sapiens

Alignment Length:	509	Identity:	128/509 - (25%)
Similarity:	206/509 - (40%)	Gaps:	145/509 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLLSP----LLPITRASQEEDTGKQDKQFTVELDPETFDTAI----AGGNVFVKFFAPWCGHCKR 70
            |.|.|    ||...|.:...|        .:||..:.|::.|    :.|.:.|:|||||||||||
Human     6 LALFPGVALLLAAARLAAASD--------VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKR 62

  Fly    71 IQPLWEQLAEIMNVDNPKVIIAKVDCTKHQGLCATHQVTGYPTLRLFKLGEEESVKFKGTRDLPA 135
            :.|.:|..|..:....|   :||||||.:...|..:.|:|||||::|:.|||... :.|.|....
Human    63 LAPEYEAAATRLKGIVP---LAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA-YDGPRTADG 123

  Fly   136 ITDFINKELSAPAEADLGEVKREQVENLNIGK---VVDLTEDTFAKHVSTGNHFVK--------- 188
            |...:.|: :.||...|.  ..|:.:.....|   :|...:|:|::   ..:.|:|
Human   124 IVSHLKKQ-AGPASVPLR--TEEEFKKFISDKDASIVGFFDDSFSE---AHSEFLKAASNLRDNY 182

  Fly   189 ----------------------FFAPWCSHCQRLAPTWEDLA-------------KELIKE---- 214
                                  .|.|  ||   |...:||..             |:.|:|
Human   183 RFAHTNVESLVNEYDDNGEGIILFRP--SH---LTNKFEDKTVAYTEQKMTSGKIKKFIQENIFG 242

  Fly   215 --PTVTISKIDCTQFRSIC-----QDFEVKGYPTLLW-----------IEDGKKIEKYSGARDLS 261
              |.:|....|..|.:.:.     .|:|.....:..|           ::.|.|:.....:|
Human   243 ICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASR--- 304

  Fly   262 TLKTYVEKMVGVPLEKTAGE---------AGDEKVVIEEVAGEEDAAKKLT-------------- 303
              ||:..::....||.||||         .|::.|:.||.:.:..|.::..
Human   305 --KTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKS 367

  Fly   304 ---------PQQLTGEDEFDQAI--AEGVAFIKFYAPWCGHCQKLQPTWEQLATETHQAQSSVKI 357
                     |.::...:.||:.:  ......|:|||||||||:.|:|.:::|. |......::.|
Human   368 EPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELG-EKLSKDPNIVI 431

  Fly   358 AKVDCTAPENKQVCIDQQVEGYPTLFLYKNGQRQN--EYEGSRSLPELQAYLKK 409
            ||:|.||   ..|....:|.|:||::.....::.|  :|||.|.|.:..:||::
Human   432 AKMDATA---NDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQR 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	41/105 (39%)
		ER_PDI_fam	39..409	CDD:273457	121/478 (25%)
		PDI_a_ERp46	167..267	CDD:239303	28/168 (17%)
		PDI_a_ERp46	303..407	CDD:239303	34/130 (26%)
PDIA3	NP_005304.3	YbbN	25..487	CDD:331940	122/490 (25%)
PDIA3	NP_005304.3	ER retention motif	502..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910