DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and pdi-6

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_509190.1	Gene:	pdi-6 / 180974	WormBaseID:	WBGene00015168	Length:	440	Species:	Caenorhabditis elegans

Alignment Length:	326	Identity:	89/326 - (27%)
Similarity:	144/326 - (44%)	Gaps:	60/326 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTRSILSVAVCGLLLSPLLPITRASQEEDTGKQDKQFTVELDPETFDTAIAGGN--VFVKFFAP 63
            :|..|:...:|||:.          |:::|        .|||....|.:.:...:  ..|:|:||
Worm     6 LLLASLAITSVCGMY----------SKKDD--------VVELTEANFQSKVINSDDIWIVEFYAP 52

  Fly    64 WCGHCKRIQPLWEQLAEIMNVDNPKVIIAK---VDCTKHQGLCATHQVTGYPTLRLFKLGEEESV 125
            ||||||.:.|.:::.|..:..      :||   ||.|:||.:...:.|.|:|||::|...:::..
Worm    53 WCGHCKSLVPEYKKAASALKG------VAKVGAVDMTQHQSVGGPYNVQGFPTLKIFGADKKKPT 111

  Fly   126 KFKGTRDLPAITDFINKELSAPAEADLGEVKREQVENLNIG-------------KVVDLTEDTFA 177
            .:.|.|...||.|.:..|......|.||. |.....:...|             :||:||:..|.
Worm   112 DYNGQRTAQAIADSVLAEAKKAVSARLGG-KSSGSSSSGSGSGSGKRGGGGSGNEVVELTDANFE 175

  Fly   178 KHV--STGNHFVKFFAPWCSHCQRLAPTWEDLAKELIKEPTVTISKIDCTQFRSICQDFEVKGYP 240
            ..|  |.....|:||||||.||:.|.|.|:..|.||  :..|.:..:|.|....:...|.::|:|
Worm   176 DLVLNSKDIWLVEFFAPWCGHCKSLEPQWKAAASEL--KGKVRLGALDATVHTVVANKFAIRGFP 238

  Fly   241 TLLWIEDGKKI---EKYSGARDLSTLKTYVEKMV--GVPLEKTAGEAGDEKVVIEEVAGEEDAAK 300
            |:.:...|..:   :.|.|.|..|.:..:.....  .:|..:.. |..:::||       |||.|
Worm   239 TIKYFAPGSDVSDAQDYDGGRQSSDIVAWASARAQENMPAPEVF-EGINQQVV-------EDACK 295

  Fly   301 K 301
            :
Worm   296 E 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	34/106 (32%)
		ER_PDI_fam	39..409	CDD:273457	82/288 (28%)
		PDI_a_ERp46	167..267	CDD:239303	34/104 (33%)
		PDI_a_ERp46	303..407	CDD:239303
pdi-6	NP_509190.1	PDI_a_P5	25..127	CDD:239299	35/115 (30%)
		PDI_a_P5	165..269	CDD:239299	34/105 (32%)
		P5_C	278..407	CDD:239281	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000934
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810