Protein Alignment prtp and pdi-2

DIOPT Version :10

• Sequence 1: NP_572742.1
• Gene: prtp / 32124
• FlyBaseID: FBgn0030329
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_508778.1
• Gene: pdi-2 / 180724
• WormBaseID: WBGene00003963
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 468
• Identity: 116/468 - (24%)
• Similarity: 195/468 - (41%)
• Gaps: 114/468 - (24%)

  Fly    34 QDKQFTVELDPETFDTAIAGGN-VFVKFFAPWCGHCKRIQPLWEQLAEIMNVDNPKVIIAKVDCT 97
            ::::..:.|..:.||..|.|.. :.|:|:||||||||.:.|.:.:.|..:..:...:.:.|:|.|
 Worm    20 EEEENVIVLTKDNFDEVINGNEFILVEFYAPWCGHCKSLAPEYAKAATQLKEEGSDIKLGKLDAT 84

  Fly    98 KHQGLCATHQVTGYPTLRLFKLGEEESVKFKGTRDLPAITDFINKE---LSAP-AEADLGEVKRE 158
            .|..:.:..:|.|||||:||:.|:.:  ::.|.||..:|..::.|:   ::.| |:||..:..:|
 Worm    85 VHGEVSSKFEVRGYPTLKLFRNGKPQ--EYNGGRDHDSIIAWLKKKTGPVAKPLADADAVKELQE 147

  Fly   159 QVENLNIGKVVDLTED---TFAKHVSTGNHFVKFFAPWCSHCQRLAPTWEDLAK---ELIKEPTV 217
            ..:.:.||...|.|.|   ||.: |:.|...|.|           ..:.||..|   ||..|..|
 Worm   148 SADVVVIGYFKDTTSDDAKTFLE-VAAGIDDVPF-----------GISTEDAVKSEIELKGEGIV 200

  Fly   218 TISKID--------------------------CTQF----RSICQDFEVKGYPTLLWIEDGKKIE 252
            ...|.|                          .::|    .|:....|:|.:..|...::..:..
 Worm   201 LFKKFDDGRVAFDEKLTQDGLKTWIQANRLALVSEFTQETASVIFGGEIKSHNLLFVSKESSEFA 265

  Fly   253 KY-----SGARDLSTLKTYVEKMVGVPLEKTA------GEAGDEKVVIEEVAGEEDAAK------ 300
            |.     :.|:.......:|  .:...:|:.|      |...||...|..::.|||..|
 Worm   266 KLEQEFKNAAKQFKGKVLFV--YINTDVEENARIMEFFGLKKDELPAIRLISLEEDMTKFKPDFE 328

  Fly   301 --------KLTPQQLTG------------ED------------EFDQAIAEGV--AFIKFYAPWC 331
                    |.|...|.|            ||            .|:|...:..  ..::||||||
 Worm   329 EITTENISKFTQNYLDGSVKPHLMSEDIPEDWDKNPVKILVGKNFEQVARDNTKNVLVEFYAPWC 393

  Fly   332 GHCQKLQPTWEQLATETHQAQSSVKIAKVDCTAPENKQVCIDQQVEGYPTLFLYKNGQRQ-NEYE 395
            |||::|.|||::|. |......|:.|||:|.|..|.:    |.:::.:||:..:..|..: .:|.
 Worm   394 GHCKQLAPTWDKLG-EKFADDESIVIAKMDSTLNEVE----DVKIQSFPTIKFFPAGSNKVVDYT 453

  Fly   396 GSRSLPELQAYLK 408
            |.|::.....:|:
 Worm   454 GDRTIEGFTKFLE 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_572742.1	PDI_a_ERp46	38..140	CDD:239303	34/102 (33%)
		PDI_a_ERp46	167..267	CDD:239303	25/140 (18%)
		PDI_a_ERp46	303..407	CDD:239303	36/130 (28%)
pdi-2	NP_508778.1	ER_PDI_fam	23..471	CDD:273457	116/465 (25%)