DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and dnj-27

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001040704.1	Gene:	dnj-27 / 173065	WormBaseID:	WBGene00001045	Length:	788	Species:	Caenorhabditis elegans

Alignment Length:	400	Identity:	99/400 - (24%)
Similarity:	175/400 - (43%)	Gaps:	79/400 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LDPETFDTAIAGGNVF-VKFFAPWCGHCKRIQPLWEQLAEIMNVDN--PKVIIAKVDCTKHQGLC 103
            |:.::::.||:||..: :.:|||||..|.::...:.:.....:.|:  ..|.|..:||.|::.||
Worm   443 LNRDSYEYAISGGEFYIIDYFAPWCPPCMKLLGEYRRFHTATSEDSMLHTVAIGSLDCVKYKDLC 507

  Fly   104 ATHQVTGYPTLRLFKLGEEESVKFKGTRDLPAITDFINKELSAPAEADLGEVKREQVENLNIGKV 168
            ....|..|||..:: ..:.::.|..|..::..|.:|::..|:    ..:.|:..||.|.|.:.:
Worm   508 QQAGVQSYPTSIVY-TPDGKTHKMVGYHNVDYILEFLDNSLN----PSVMEMSPEQFEELVMNR- 566

  Fly   169 VDLTEDTFAKHVSTGNHFVKFFAPWCSHCQRLAPTWEDLAKELIK-EPTVTISKIDCTQFRSICQ 232
              ..|:|:         .|.||||||..||:|||..:..|:::.. :....::.|||.::...|.
Worm   567 --KDEETW---------LVDFFAPWCGPCQQLAPELQKAARQIAAFDENAHVASIDCQKYAQFCT 620

  Fly   233 DFEVKGYPTLLWIEDGKKIEKYSGA----------RDLSTLKTYVEKMVGVPLEKTAGEAGDEKV 287
            :.::..|||:. :...||.::...:          |:..:::.:|...  :|.|..:
Worm   621 NTQINSYPTVR-MYPAKKTKQPRRSPFYDYPNHMWRNSDSIQRWVYNF--LPTEVVS-------- 674

  Fly   288 VIEEVAGEEDAAKKLTPQQLTGEDEFDQAIAEGVA--FIKFYAPWCGHCQKLQPTWEQLATETHQ 350
                                .|.| |...:.:...  .:.|:|||||||.:..|.::|:|.|
Worm   675 --------------------LGND-FHTTVLDSSEPWIVDFFAPWCGHCIQFAPIYDQIAKE--- 715

  Fly   351 AQSSVKIAKVDCTAPENKQVCIDQQVEGYPTLFLY--KNG-QRQNEYEGSRSLPELQAYLK---- 408
            ....|..||:||  .:...||...||..|||:.||  |.| .||.:..........:.:::
Worm   716 LAGKVNFAKIDC--DQWPGVCQGAQVRAYPTIRLYTGKTGWSRQGDQGIGIGTQHKEQFIQIVRQ 778

  Fly   409 --KFLGHDEL 416
              |...||||
Worm   779 QLKLDEHDEL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303	26/100 (26%)
		ER_PDI_fam	39..409	CDD:273457	94/391 (24%)
		PDI_a_ERp46	167..267	CDD:239303	25/110 (23%)
		PDI_a_ERp46	303..407	CDD:239303	33/108 (31%)
dnj-27	NP_001040704.1	DnaJ	18..>150	CDD:223560
		DnaJ	20..82	CDD:278647
		PDI_a_ERdj5_N	116..214	CDD:239301
		Thioredoxin_like	222..>312	CDD:294274
		ER_PDI_fam	438..750	CDD:273457	90/360 (25%)
		PDI_a_ERdj5_C	438..543	CDD:239302	26/100 (26%)
		PDI_a_ERdj5_C	549..664	CDD:239302	30/127 (24%)
		PDI_a_ERdj5_C	670..773	CDD:239302	34/136 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D522268at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920