DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prtp and PDIA6

DIOPT Version :9

Sequence 1:	NP_001188583.1	Gene:	prtp / 32124	FlyBaseID:	FBgn0030329	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001269633.1	Gene:	PDIA6 / 10130	HGNCID:	30168	Length:	492	Species:	Homo sapiens

Alignment Length:	250	Identity:	77/250 - (30%)
Similarity:	132/250 - (52%)	Gaps:	29/250 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 VVDLTEDTFAKHV--STGNHFVKFFAPWCSHCQRLAPTWEDLAKELIKEPTVTISKIDCTQFRSI 230
            |::||...|.:.|  |.....|:|:||||.|||||.|.|:..|..|  :..|.:..:|..:..|:
Human    79 VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATAL--KDVVKVGAVDADKHHSL 141

  Fly   231 CQDFEVKGYPTL-LWIEDGKKIEKYSGARD--------LSTLKTYVEKMVGVPLEKTAGEAGDEK 286
            ...:.|:|:||: ::..:..:.|.|.|.|.        ||.|:..|:..:|   .::.|.:..::
Human   142 GGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLG---GRSGGYSSGKQ 203

  Fly   287 VVIEEVAGEEDAAKKLTPQQLTGEDEFDQAI--AEGVAFIKFYAPWCGHCQKLQPTWEQLATET- 348
                   |..|::.|....:|| :|.||:.:  :|.|..::|||||||||:.|:|.|...|:|.
Human   204 -------GRSDSSSKKDVIELT-DDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVK 260

  Fly   349 HQAQSSVKIAKVDCTAPENKQVCIDQQVEGYPTLFLYKNGQRQNEYEGSRSLPEL 403
            .|.:..||:|.||.|.  |:.:.....:.|:||:.:::.|:...:|:|.|:..::
Human   261 EQTKGKVKLAAVDATV--NQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDI 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prtp	NP_001188583.1	PDI_a_ERp46	38..140	CDD:239303
		ER_PDI_fam	39..409	CDD:273457	77/249 (31%)
		PDI_a_ERp46	167..267	CDD:239303	35/109 (32%)
		PDI_a_ERp46	303..407	CDD:239303	36/103 (35%)
PDIA6	NP_001269633.1	PDI_a_P5	78..180	CDD:239299	32/102 (31%)
		PDI_a_P5	213..318	CDD:239299	36/103 (35%)
		P5_C	327..456	CDD:239281
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000934
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810