Protein Alignment PhKgamma and RAD53

DIOPT Version :10

• Sequence 1: NP_511129.3
• Gene: PhKgamma / 32120
• FlyBaseID: FBgn0011754
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_015172.1
• Gene: RAD53 / 855950
• SGDID: S000006074
• Length: 821
• Species: Saccharomyces cerevisiae
• Alignment Length: 570
• Identity: 139/570 - (24%)
• Similarity: 231/570 - (40%)
• Gaps: 149/570 - (26%)

  Fly    27 EILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYII 91
            |::|:|..:||::.||:.|||.||.|||        .:......::...:|:.:| |.:.||.|:
Yeast   202 EVVGQGAFATVKKAIERTTGKTFAVKII--------SKRKVIGNMDGVTRELEVL-QKLNHPRIV 257

  Fly    92 DLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKP 156
            .|:..:|.....::|.|....|:|.|::.:...:.|...|.|.|||...::|||:..|.||||||
Yeast   258 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKP 322

  Fly   157 ENILLDENHN--VKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPG-------YSQ 212
            :|||::::..  |||||||.||....|..:...|||..|:|||.::......||.       ||.
Yeast   323 DNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSS 387

  Fly   213 EVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPS 277
            .||:|:.|.:::.:|.|..||....|..:.:.|..|.|.....:...|||:.:|.|...|.|||:
Yeast   388 LVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPN 452

  Fly   278 QRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPEASSY-RFGQLNSSCAGAPNYL 341
            .|.|..:.|.||:. :|..:|                       :.|| .|.|::.|
Yeast   453 NRSTAAKALNHPWI-KMSPLG-----------------------SQSYGDFSQISLS-------- 485

  Fly   342 YCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTTANTSNSALASASSHKTLT 406
                 .|.|..::.:. :|||......|...:
Yeast   486 -----QSLSQQKLLEN-MDDAQYEFVKAQRKL--------------------------------- 511

  Fly   407 AMVYYQQQPQQHQTQQQQQQYQQQQTTQLPVQLQLQHPLLQTGGDGKQSVYAPP---TVQLRKQS 468
                  |..||.|.|.|:.|..:.|..::|....::              |..|   ..:.|:|.
Yeast   512 ------QMEQQLQEQDQEDQDGKIQGFKIPAHAPIR--------------YTQPKSIEAETREQK 556

  Fly   469 RF---------NARKKFQFAILVIR----AIIRIRRLRFTAEPLHVEEAIRDPYRVKVLR----K 516
            ..         :::||.....|.::    :||:        |.|.:::.: :|:.:....    |
Yeast   557 LLHSNNTENVKSSKKKGNGRFLTLKPLPDSIIQ--------ESLEIQQGV-NPFFIGRSEDCNCK 612

  Fly   517 VIDGCAFRVYGHWVKKGEGQNRAALFENTPR---------TELHALYINN 557
            :.|....||:....||.....: :::|:..:         |..:..|:||
Yeast   613 IEDNRLSRVHCFIFKKRHAVGK-SMYESPAQGLDDIWYCHTGTNVSYLNN 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	94/272 (35%)
RAD53	NP_015172.1	FHA_RAD53-like_rpt1	35..148	CDD:438741
		STKc_Rad53_Cds1	196..465	CDD:271000	93/271 (34%)
		FHA_RAD53-like_rpt2	577..695	CDD:438742	17/95 (18%)