DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PhKgamma and MEK1

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_014996.3	Gene:	MEK1 / 854533	SGDID:	S000005878	Length:	497	Species:	Saccharomyces cerevisiae

Alignment Length:	362	Identity:	96/362 - (26%)
Similarity:	157/362 - (43%)	Gaps:	84/362 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DDLLPDKDA----AKGFYAKYEPKEILGRGI-SSTVRRCIEKETGKE-----------FAAKIID 55
            |||....|.    ..||..:.:..||..|.: :.|....:.....||           :|.|||.
Yeast   138 DDLQSSLDPKLLDQMGFLREVDQWEITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIK 202

  Fly    56 LGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVF-ESDAFVFLVFELCPKGELFDYL 119
            |       :.|.:.      :|..||.: :.||.||.:...| :.:..:::..:|.|.|:||.||
Yeast   203 L-------KPNKFD------KEARILLR-LDHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYL 253

  Fly   120 TS---VVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILL---DENHNVKITDFGFAKQL 178
            ..   :.::||.::..|:.||.:.:.|:|.:.|||||||.:||||   :....:.:.|||.||.|
Yeast   254 AKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDL 318

  Fly   179 QEG-EKLTNLCGTPGYLAPE-----------------TLKCNMFEGSPGYSQEVDIWACGVIMFT 225
            ... |::..:.|||.|.|||                 ||:      ..||..:.|:|:.|||...
Yeast   319 NSNKERMHTVVGTPEYCAPEVGFRANRKAYQSFSRAATLE------QRGYDSKCDLWSLGVITHI 377

  Fly   226 LLVGCPPFW-HRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHP 289
            :|.|..||: ...:..:::|...||.:|...:|..:|::.|..::..|..|..:|:..|:.|:|.
Yeast   378 MLTGISPFYGDGSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHI 442

  Fly   290 FFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPEASSYR 326
            :.                      ::||.|.|...|:
Yeast   443 WI----------------------AKHLSQLERLYYK 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	86/309 (28%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	85/305 (28%)
MEK1	NP_014996.3	FHA	28..122	CDD:238017
MEK1	NP_014996.3	STKc_CAMK	160..443	CDD:270687	85/302 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4277
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030