DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and DCLK3

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001381601.1	Gene:	DCLK3 / 85443	HGNCID:	19005	Length:	817	Species:	Homo sapiens

Alignment Length:	274	Identity:	103/274 - (37%)
Similarity:	154/274 - (56%)	Gaps:	23/274 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGH 87
            ||...::|.|..:.|:.|..:||.:.:|.||||     :|.......|:::   ||.|: |.:.|
Human   525 YETGRVIGDGNFAVVKECRHRETRQAYAMKIID-----KSRLKGKEDMVDS---EILII-QSLSH 580

  Fly    88 PYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHR 152
            |.|:.|.:|:|:|..::|:.|....|:|||.:...|...|.....::..:.:.:.::|.||||||
Human   581 PNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHR 645

  Fly   153 DLKPENILLDENHN----VKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQE 213
            ||||||:|:..|.:    :|:.|||.||.:.  ..:..:||||.|:|||.|      ...||..|
Human   646 DLKPENLLVQRNEDKSTTLKLADFGLAKHVV--RPIFTVCGTPTYVAPEIL------SEKGYGLE 702

  Fly   214 VDIWACGVIMFTLLVGCPPFW--HRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDP 276
            ||:||.|||::.||.|.|||.  .|.|..:...|..|.:.|..|.|.:||:..|||:.:.|||||
Human   703 VDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDP 767

  Fly   277 SQRITVKEVLRHPF 290
            .:|.|..:||:||:
Human   768 KKRYTAHQVLQHPW 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	103/274 (38%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	103/274 (38%)
DCLK3	NP_001381601.1	DCX_DCLK3	93..177	CDD:340528
DCLK3	NP_001381601.1	STKc_DCKL3	524..781	CDD:271087	102/272 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920