Protein Alignment PhKgamma and CAMK2G

DIOPT Version :10

• Sequence 1: NP_511129.3
• Gene: PhKgamma / 32120
• FlyBaseID: FBgn0011754
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001307827.1
• Gene: CAMK2G / 818
• HGNCID: 1463
• Length: 592
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 150/475 - (31%)
• Similarity: 234/475 - (49%)
• Gaps: 64/475 - (13%)

  Fly    19 FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQ 83
            |...|:..|.||:|..|.||||::|.:.:|:|||||:    |:......:..||   :|..|.|
Human    10 FTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIIN----TKKLSARDHQKLE---REARICR- 66

  Fly    84 VMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKS 148
            ::.||.|:.|.|....:.|.:|||:|...||||:.:.:....||......:.||.|.|.:||...
Human    67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131

  Fly   149 IVHRDLKPENILLD---ENHNVKITDFGFAKQLQ-EGEKLTNLCGTPGYLAPETLKCNMFEGSPG 209
            ||||||||||:||.   :...||:.|||.|.::| |.:......||||||:||.|:      ...
Human   132 IVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR------KDP 190

  Fly   210 YSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVV 274
            |.:.|||||||||::.||||.||||...|..:.:.|..|.|.|.||||..::.:.|:||.:.|.:
Human   191 YGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTI 255

  Fly   275 DPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPI-APAQTNSRHLLQPE-------ASSYRFGQLN 331
            :|::|||..:.|:||:..|...:....|....: ...:.|:|..|:..       :.::..|:.:
Human   256 NPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQS 320

  Fly   332 SSCAG-APNYLYCAPQSSYS-SNRMRDGALDDAGASAASATCHVMSPS-----NAS-----NSYA 384
            |:.|. |.:....|.|::.| .|:..||.:.   ...:|::.|:|.|.     ||:     ::.:
Human   321 SAPASPAASAAGLAGQAAKSLLNKKSDGGVK---KRKSSSSVHLMEPQTTVVHNATDGIKGSTES 382

  Fly   385 TNTTA----------NTSN-SALASASSHKTLTA-MVYYQQQPQQHQTQQQQQQYQQQQTTQLPV 437
            .|||.          .|.| |::....|.:..|| ....|.||....:..::|:.
Human   383 CNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEI---------- 437

  Fly   438 QLQLQHPLLQTGGDGKQSVY 457
             :::...|::...:|....|
Human   438 -IKITEQLIEAINNGDFEAY 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	113/275 (41%)
CAMK2G	NP_001307827.1	STKc_CaMKII	12..303	CDD:270988	117/304 (38%)
		NTF2_like	433..>488	CDD:471850	4/35 (11%)