DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and CAMK2B

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_011513849.1	Gene:	CAMK2B / 816	HGNCID:	1461	Length:	709	Species:	Homo sapiens

Alignment Length:	389	Identity:	129/389 - (33%)
Similarity:	195/389 - (50%)	Gaps:	39/389 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQ 83
            |..:|:..|.:|:|..|.||||::..||.|:|||||:    |:......:..||   :|..|.|
Human    10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIIN----TKKLSARDHQKLE---REARICR- 66

  Fly    84 VMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKS 148
            ::.|..|:.|.|....:.|.:|||:|...||||:.:.:....||......::||.|.|.:.|...
Human    67 LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131

  Fly   149 IVHRDLKPENILLD---ENHNVKITDFGFAKQLQ-EGEKLTNLCGTPGYLAPETLKCNMFEGSPG 209
            :|||||||||:||.   :...||:.|||.|.::| :.:......||||||:||.|:      ...
Human   132 VVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR------KEA 190

  Fly   210 YSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVV 274
            |.:.|||||||||::.||||.||||...|..:.:.|..|.|.|.||||..::.:.|:||.:.|.:
Human   191 YGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTI 255

  Fly   275 DPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPI-APAQTNSRHLLQPEASSYRFGQLNSSCAGAP 338
            :|::|||..|.|:||:..|...:....|....: ...:.|:|..|:        |.:.::.....
Human   256 NPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLK--------GAILTTMLATR 312

  Fly   339 NYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNT---TANTSNSALASA 399
            |         :|..|........:.|::.:....|....:..|..|...   |.:|.|||.|::
Human   313 N---------FSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATS 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	110/275 (40%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	109/271 (40%)
CAMK2B	XP_011513849.1	STKc_CaMKII	12..303	CDD:270988	114/312 (37%)
		S_TKc	14..272	CDD:214567	109/271 (40%)
		CaMKII_AD	577..704	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920