DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and phkg2

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_012825992.1	Gene:	phkg2 / 779740	XenbaseID:	XB-GENE-994728	Length:	395	Species:	Xenopus tropicalis

Alignment Length:	557	Identity:	223/557 - (40%)
Similarity:	286/557 - (51%)	Gaps:	176/557 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKD-EEDDLLPDKDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGE 64
            |.:| |..|.|||...||.||.||:||||:|||:||||||||.:|||:::|.|||::  |.|  .
Frog     1 MTRDAEARDELPDWAGAKEFYQKYDPKEIIGRGVSSTVRRCIHRETGRQYAVKIIEV--TPE--R 61

  Fly    65 TNPYHMLE---ATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLS 126
            .:|..:.|   :|.:|:.||..|..||.||.|.|.:||..|:||||:|..:||||||||..||||
Frog    62 LSPEQLKEVRLSTAKEMEILHHVSNHPSIISLIDSYESSTFIFLVFDLMKRGELFDYLTEKVTLS 126

  Fly   127 EKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTP 191
            ||:||.|||.:.|.|.|:|:.:||||||||||||:|:..|:|::||||:..|:..|||..|||||
Frog   127 EKETRCIMRSLLEAVTYLHSNNIVHRDLKPENILMDDCLNIKLSDFGFSCILKPTEKLRELCGTP 191

  Fly   192 GYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPE 256
            ||||||.|||:|.|..|||.:|||:|||||||||||.|.|||||||||:|||.||:|::.|.|||
Frog   192 GYLAPEILKCSMDETHPGYGREVDLWACGVIMFTLLAGSPPFWHRKQMLMLRMIMDGRFQFGSPE 256

  Fly   257 WADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPE 321
            |.|.|...||||.:.|.|.|.:|:|.::.|:||||                   |::.|....|.
Frog   257 WDDRSSTVKDLICRLLEVCPEKRLTAEQALQHPFF-------------------QSHQRDQDTPV 302

  Fly   322 ASSYRFGQLNSSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATN 386
            ..||||                         |:         |:.|:..|
Frog   303 KPSYRF-------------------------RI---------AAWAALAC--------------- 318

  Fly   387 TTANTSNSALASASSHKTLTAMVYYQQQPQQHQTQQQQQQYQQQQTTQLPVQLQLQHPLLQTGGD 451

Frog   319 ----------------------------------------------------------------- 318

  Fly   452 GKQSVYAPPTVQLRKQSRFNARKKFQFAILVIRAIIRIRRLRFTAEPLHVEEAIRDPYRVKVLRK 516
                                           :|.::|.||    |.|:..:..:||||.:|.:|:
Frog   319 -------------------------------VRILVRWRR----ARPVTTQLLMRDPYGIKGVRR 348

  Fly   517 VIDGCAFRVYGHWVKKGEGQNRAALFENTPRTELHAL 553
            :||.||||:|||||||||.|||||||:|.|:..|.|:
Frog   349 LIDACAFRIYGHWVKKGERQNRAALFQNQPKALLLAM 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	163/274 (59%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	160/270 (59%)
phkg2	XP_012825992.1	STKc_PhKG2	13..291	CDD:271083	166/281 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	332	1.000	Domainoid score	I1150
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1603
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0002585
OrthoInspector	1	1.000	-	-		otm47985
Panther	1	1.100	-	-	LDO	PTHR44167
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4277
SonicParanoid	1	1.000	-	-		X1942
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190