DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and camk2b1

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_021331894.1	Gene:	camk2b1 / 562064	ZFINID:	ZDB-GENE-030131-9588	Length:	693	Species:	Danio rerio

Alignment Length:	404	Identity:	134/404 - (33%)
Similarity:	208/404 - (51%)	Gaps:	35/404 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQ 83
            |..:|:..|.||:|..|.||||::..||:|:|||||:    |:......:..||   :|..|.|
Zfish     9 FTDEYQLYEELGKGAFSVVRRCVKLSTGQEYAAKIIN----TKKLSARDHQKLE---REARICR- 65

  Fly    84 VMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKS 148
            ::.||.|:.|.|....:.|.:|:|:|...||||:.:.:....||......::||.|.|.:.|...
Zfish    66 LLKHPNIVRLHDSISEEGFHYLLFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 130

  Fly   149 IVHRDLKPENILLD---ENHNVKITDFGFAKQLQ-EGEKLTNLCGTPGYLAPETLKCNMFEGSPG 209
            :|||||||||:||.   :|..||:.|||.|.::| :.:......||||||:||.|:      ...
Zfish   131 VVHRDLKPENLLLASKCKNAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR------KEA 189

  Fly   210 YSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVV 274
            |.:.|||||||||::.||||.||||...|..:.:.|..|.|.|.||||..::.:.|:||.:.|.:
Zfish   190 YGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTI 254

  Fly   275 DPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPI-APAQTNSRHLLQPEASSYRFGQLNSSCAG-- 336
            :|::|||.:|.|:||:..|...:....|....: ...:.|:|..|:....:......|.|...
Zfish   255 NPAKRITAQEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLVSRNFSVGSRQ 319

  Fly   337 --APNYLYCAPQSSYSSNRMRDGALDDAGAS-----------AASATCHVMSPSNAS-NSYATNT 387
              ||..:..|..:..::.....|.::.|..:           .:|:|...|..:|:: ||..|:.
Zfish   320 TTAPASVTAAAAAVAAAAGTTAGLVEQAAKTLLNKKADVKKRKSSSTIQYMPQTNSTKNSIVTSP 384

  Fly   388 TANTSNSALASASS 401
            ..|..:.||.:.::
Zfish   385 KGNLPSPALEAQTT 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	112/275 (41%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	111/271 (41%)
camk2b1	XP_021331894.1	STKc_CaMKII	11..302	CDD:270988	116/304 (38%)
camk2b1	XP_021331894.1	CaMKII_AD	561..688	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920