DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and dclk1a

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_005172728.1	Gene:	dclk1a / 558997	ZFINID:	ZDB-GENE-061013-124	Length:	770	Species:	Danio rerio

Alignment Length:	355	Identity:	110/355 - (30%)
Similarity:	177/355 - (49%)	Gaps:	46/355 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEEDDLLPDKDAAK---------GFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGAT 59
            |||:..:.|.:..:         ....:|:...::|.|..:.|..|:|..|.:.:|.|||:.|..
Zfish   355 DEEEGPVSDAETLEETPIPTVPSSISDRYKVGRMIGDGNFAVVHECVEHSTDRAYALKIINKGKC 419

  Fly    60 TESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVT 124
                 ....||::   .|::|||:|. ||.|:.|.:..::...::||.||...|:|||.:||...
Zfish   420 -----RGKEHMIQ---NEVAILRRVK-HPNIVLLIEEMDTYNELYLVMELVKGGDLFDAITSANR 475

  Fly   125 LSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILL----DENHNVKITDFGFAKQLQEGEKLT 185
            .:|:....::..:...::|:|:.:|||||:||||:|:    |.:.::|:.|||.| .:.:| .|.
Zfish   476 YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA-TVVDG-PLY 538

  Fly   186 NLCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPF--WHRKQMVMLRNIMEG 248
            .:||||.|:|||.:      ...||..:|||||.|||.:.||.|.|||  ....|..:...|:.|
Zfish   539 TVCGTPTYVAPEII------AETGYGLKVDIWAAGVITYILLCGFPPFRGSTEDQEALFDQILLG 597

  Fly   249 KYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFF---------NQMVLMGD-RRH- 302
            :..|..|.|.::|:..|:||...|.|:..||.|..:||.||:.         :|:.:.|. ::|
Zfish   598 QLEFPLPYWDNVSDSAKELIVSMLQVEVDQRYTALQVLEHPWVTNDGLSENEHQLSVAGKIKKHF 662

  Fly   303 ---PAPPIAPAQTNSRHLLQPEASSYRFGQ 329
               |.|........:...|..|....|.|:
Zfish   663 NTGPKPNTPGVTVMTTTALDKERQILRRGR 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	97/277 (35%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	97/273 (36%)
dclk1a	XP_005172728.1	DCX	46..137	CDD:214711
		DCX	174..262	CDD:214711
		STKc_DCKL1	376..643	CDD:271085	97/283 (34%)
		S_TKc	383..640	CDD:214567	97/273 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010