DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and phkg1b

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_005161235.2	Gene:	phkg1b / 554046	ZFINID:	ZDB-GENE-050522-52	Length:	450	Species:	Danio rerio

Alignment Length:	557	Identity:	219/557 - (39%)
Similarity:	278/557 - (49%)	Gaps:	185/557 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKDEEDDLLPDKDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGET 65
            |.|:||:   ||....:.||.||:||||||||:||.||||::|.||:|:|.||||:   |.|.:.
Zfish     1 MTKEEEN---PDWVGGQEFYDKYDPKEILGRGVSSVVRRCVDKRTGQEYAVKIIDI---TPSDKM 59

  Fly    66 NPYHMLE---ATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSE 127
            .|..:.|   ||.:||.|||:|.|...||.|:|.|||.||.||||:|..:||||||||..|||||
Zfish    60 TPQEIQEIQQATVKEIDILRKVSGQKNIIQLKDCFESKAFFFLVFDLMKRGELFDYLTEKVTLSE 124

  Fly   128 KKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPG 192
            |:||.|:|.:.|.|||:||.:||||||||||||||::.|:|:|||||:.|::.|::|..:|||||
Zfish   125 KETRKIIRALLEVVEYLHAHNIVHRDLKPENILLDDDVNIKLTDFGFSIQIEPGQRLNEVCGTPG 189

  Fly   193 YLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEW 257
            |||||.::|:|.....||...||:|:.|||::|||.|.|||||||||:|||.|:.|:|.|.||||
Zfish   190 YLAPEIIECSMDPKHSGYGTAVDLWSTGVILYTLLAGSPPFWHRKQMLMLRLILAGQYQFNSPEW 254

  Fly   258 ADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPEA 322
            .|.|:..||||.:.|||||..|.|..|.|.||||.|.| :.:.||.:|
Zfish   255 DDRSDTVKDLISRLLVVDPESRYTATEALNHPFFQQYV-VAEVRHFSP----------------- 301

  Fly   323 SSYRFGQLNSSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNT 387
              ||
Zfish   302 --YR------------------------------------------------------------- 303

  Fly   388 TANTSNSALASASSHKTLTAMVYYQQQPQQHQTQQQQQQYQQQQTTQLPVQLQLQHPLLQTGGDG 452

Zfish   304 ----------------------------------------------------------------- 303

  Fly   453 KQSVYAPPTVQLRKQSRFNARKKFQFAILVIRAIIRI----RRLRFTAEPLHVEEAIRDPYRVKV 513
                                  ||:.....:.|.:||    ||    |:|:..|....|||.:|.
Zfish   304 ----------------------KFKVICRTVLAAMRIYCNYRR----AKPVTKEVIQSDPYAIKH 342

  Fly   514 LRKVIDGCAFRVYGHWVKKGEGQNRAALFENTPRTEL 550
            |||:||.|||::||||||||:.|||||||||:|:..|
Zfish   343 LRKMIDACAFKIYGHWVKKGQTQNRAALFENSPKVIL 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	163/274 (59%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	160/270 (59%)
phkg1b	XP_005161235.2	PKc_like	16..291	CDD:304357	165/277 (60%)
phkg1b	XP_005161235.2	Pkinase	20..288	CDD:278497	160/270 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1086
eggNOG	1	0.900	-	-		E1_KOG0599
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1661
OMA	1	1.010	-	-		QHG48604
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0002585
OrthoInspector	1	1.000	-	-		otm24846
orthoMCL	1	0.900	-	-		OOG6_105085
Panther	1	1.100	-	-	LDO	PTHR44167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1942
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840