DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and Camk1

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_598687.1	Gene:	Camk1 / 52163	MGIID:	1098535	Length:	374	Species:	Mus musculus

Alignment Length:	280	Identity:	104/280 - (37%)
Similarity:	153/280 - (54%)	Gaps:	23/280 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGH 87
            |:.:::||.|..|.|....:|.|.|..|.|.|...| .|..|       .:...||::|.::. |
Mouse    20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKA-LEGKE-------GSMENEIAVLHKIK-H 75

  Fly    88 PYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHR 152
            |.|:.|.|::||...::|:.:|...|||||.:......:|:....::.|:.:.|:|:|...||||
Mouse    76 PNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHR 140

  Fly   153 DLKPENIL---LDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQEV 214
            ||||||:|   |||:..:.|:|||.:|....|..|:..||||||:|||.|      ....||:.|
Mouse   141 DLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL------AQKPYSKAV 199

  Fly   215 DIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQR 279
            |.|:.|||.:.||.|.|||:......:...|::.:|.|.||.|.|||:..||.||..:..||.:|
Mouse   200 DCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKR 264

  Fly   280 ITVKEVLRHPFFNQMVLMGD 299
            .|.::.|:||:     :.||
Mouse   265 FTCEQALQHPW-----IAGD 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	102/270 (38%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	102/270 (38%)
Camk1	NP_598687.1	STKc_CaMKI_alpha	16..278	CDD:271069	102/277 (37%)
		Autoinhibitory domain. /evidence=ECO:0000250	276..316		2/4 (50%)
		Calmodulin-binding. /evidence=ECO:0000250	296..317
		Nuclear export signal. /evidence=ECO:0000250	315..321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920