DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PhKgamma and MYLK

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_024309300.1	Gene:	MYLK / 4638	HGNCID:	7590	Length:	1924	Species:	Homo sapiens

Alignment Length:	421	Identity:	127/421 - (30%)
Similarity:	182/421 - (43%)	Gaps:	67/421 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KDE-----EDDLLPDKD----------AAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAK 52
            |||     :|:..|:.|          ....|   |:.:|.||.|....|.|.:||:|.|.:|.|
Human  1442 KDEVEVSDDDEKEPEVDYRTVTINTEQKVSDF---YDIEERLGSGKFGQVFRLVEKKTRKVWAGK 1503

  Fly    53 IIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFD 117
            .....:..|.         |..||||||: ..:.||.::...|.||..|.:.:|.|:...||||:
Human  1504 FFKAYSAKEK---------ENIRQEISIM-NCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFE 1558

  Fly   118 -YLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILL--DENHNVKITDFGFAKQLQ 179
             .:.....|:|::....||||.|||||||.:.|||.|||||||:.  .....:|:.|||.|::|:
Human  1559 RIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLE 1623

  Fly   180 EGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRN 244
            ....|..|.|||.::|||.:.....    ||:  .|:|:.|||.:.|:.|..||........|.|
Human  1624 NAGSLKVLFGTPEFVAPEVINYEPI----GYA--TDMWSIGVICYILVSGLSPFMGDNDNETLAN 1682

  Fly   245 IMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAP 309
            :....:.|....:.:||:|.||.|...|..|...|:...:.|:||:     ||.|.::
Human  1683 VTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPW-----LMKDTKN------- 1735

  Fly   310 AQTNSRHLLQPEASSY---RFGQLNSSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAASATC 371
              ..::.|.:.....|   |..|...:...|...|        ||..|..| |....:|..|.|
Human  1736 --MEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRL--------SSMAMISG-LSGRKSSTGSPT- 1788

  Fly   372 HVMSPSNASNSYATNTTANTSNSALASASSH 402
               ||.||....:....:.....|:|....|
Human  1789 ---SPLNAEKLESEEDVSQAFLEAVAEEKPH 1816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	97/274 (35%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	96/270 (36%)
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352
		23ISL	261..422	CDD:318761
		I-set	424..514	CDD:254352
		I-set	524..610	CDD:254352
		I-set	633..722	CDD:254352
		I-set	731..819	CDD:254352
		I-set	1108..1197	CDD:254352
		Ig8_hMLCK_like	1248..1345	CDD:143239
		FN3	1341..1433	CDD:238020
		STKc_MLCK1	1471..1729	CDD:271093	97/281 (35%)
		I-set	1819..1909	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010