DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and camk2d2

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_009304932.1	Gene:	camk2d2 / 436815	ZFINID:	ZDB-GENE-040718-277	Length:	554	Species:	Danio rerio

Alignment Length:	459	Identity:	146/459 - (31%)
Similarity:	223/459 - (48%)	Gaps:	40/459 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQ 83
            |..:|:..|.||:|..|.||||::..:|:|:|||||:    |:......:..||   :|..|.|
Zfish     9 FTDEYQLFEELGKGAFSVVRRCVKISSGQEYAAKIIN----TKKLSARDHQKLE---REARICR- 65

  Fly    84 VMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKS 148
            ::.||.|:.|.|....:.|.:|||:|...||||:.:.:....||......::||.|.|.:.|...
Zfish    66 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVHHCHVNG 130

  Fly   149 IVHRDLKPENILLDENHN---VKITDFGFAKQLQ-EGEKLTNLCGTPGYLAPETLKCNMFEGSPG 209
            ||||||||||:||.....   ||:.|||.|.::| :.:......||||||:||.|:      ...
Zfish   131 IVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR------KDP 189

  Fly   210 YSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVV 274
            |.:.||:||||||::.||||.||||...|..:.:.|..|.|.|.||||..::.:.||||.|.|.:
Zfish   190 YGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTI 254

  Fly   275 DPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPI-APAQTNSRHLLQPEASSYRFGQLNSSCAGAP 338
            :||:|||..|.|:||:..|...:....|....: ...:.|:|..|:....:......|.|  .|.
Zfish   255 NPSKRITAAEALKHPWICQRSTVASMMHRQETVECLKKFNARRKLKGAILTTLLVTRNFS--AAK 317

  Fly   339 NYLYCAPQSSYSSNRMR-DGALDDAGASAA----SATCHVMSPSNASNSYATNTTANTSNSALAS 398
            :.|...|.....:|:.. ..:..|.|.:.|    :...|.....|..::.:.|||....:   ..
Zfish   318 SLLNKKPDGVKVNNKTNLASSPKDTGPAPALEPQTTVIHNPVDRNKESTESANTTIEDED---LK 379

  Fly   399 ASSHKTLTAMVYYQQ---QPQQHQTQQQQQQYQQQQTTQLPVQ------LQLQHPLLQTGGDGKQ 454
            |.....|:....:|.   :||  .::.:|......||.|:..:      :::...|:::..:|..
Zfish   380 ARRFGNLSINSIWQPSVGRPQ--NSEPKQAPNSSVQTCQVINKARKQEIIKVTEQLIESINNGDF 442

  Fly   455 SVYA 458
            ..||
Zfish   443 EAYA 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	114/275 (41%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	113/271 (42%)
camk2d2	XP_009304932.1	STKc_CaMKII	11..302	CDD:270988	118/304 (39%)
		S_TKc	13..271	CDD:214567	113/271 (42%)
		CaMKII_AD	422..549	CDD:285524	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920