DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and Camk4

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_036859.2	Gene:	Camk4 / 25050	RGDID:	2264	Length:	474	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	131/454 - (28%)
Similarity:	221/454 - (48%)	Gaps:	77/454 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DDLLPD-------KDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGE 64
            ::|:||       :|....|   :|.:..||||.:|.|.||.:|.|.|.:|.|:  |..|.:.
  Rat    22 ENLVPDYWIDGSKRDPLSDF---FEVESELGRGATSIVYRCKQKGTQKPYALKV--LKKTVDK-- 79

  Fly    65 TNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKK 129
                   :..|.||.:|.: :.||.||.|:::||:...:.||.||...|||||.:......||:.
  Rat    80 -------KIVRTEIGVLLR-LSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERD 136

  Fly   130 TRTIMRQIFEGVEYIHAKSIVHRDLKPENILL---DENHNVKITDFGFAKQLQEGEKLTNLCGTP 191
            ....::||.|.|.|:|...||||||||||:|.   ..:..:||.|||.:|.::....:..:||||
  Rat   137 AADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTP 201

  Fly   192 GYLAPETLK-CNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFW-HRKQMVMLRNIMEGKYSFTS 254
            ||.|||.|: |       .|..|||:|:.|:|.:.||.|..||: .|....|.|.|:..:|.|.|
  Rat   202 GYCAPEILRGC-------AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFIS 259

  Fly   255 PEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQ 319
            |.|.::|.:.|||::|.:|:||.:|:|..:.|:||:                :.....|..|:
  Rat   260 PWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQHPW----------------VTGKAANFVHM-- 306

  Fly   320 PEASSYRFGQLNSSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYA 384
             :.:..:..:.|     |...|..|.::..:|:|:         .||:|:..::...:.||:...
  Rat   307 -DTAQKKLQEFN-----ARRKLKAAVKAVVASSRL---------GSASSSHTNIQESNKASSEAQ 356

  Fly   385 TNTTANTSNSALAS---ASSHKTLTA-----MVYYQQQPQQHQ--TQQQQQQYQQQQTTQLPVQ 438
            ...........|.:   |..|:...|     |....::.::.:  .::::::.::::|:::..|
  Rat   357 PAQDGKDKTDPLENKMQAGDHEAAKAAADETMKLQSEEVEEEEGVKEEEEEEEEEEETSRMVPQ 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	107/276 (39%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	106/272 (39%)
Camk4	NP_036859.2	STKc_CaMKIV	38..331	CDD:270987	113/338 (33%)
		Autoinhibitory domain	297..336		8/55 (15%)
		PP2A-binding. /evidence=ECO:0000250	302..319		3/24 (13%)
		Calmodulin-binding. /evidence=ECO:0000255	318..337		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..474		12/85 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920