DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and Camk2a

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_006525604.1	Gene:	Camk2a / 12322	MGIID:	88256	Length:	489	Species:	Mus musculus

Alignment Length:	376	Identity:	128/376 - (34%)
Similarity:	190/376 - (50%)	Gaps:	42/376 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQ 83
            |..:|:..|.||:|..|.||||::...|:|:|||||:    |:......:..||   :|..|.|
Mouse     9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIIN----TKKLSARDHQKLE---REARICR- 65

  Fly    84 VMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKS 148
            ::.||.|:.|.|....:...:|:|:|...||||:.:.:....||......::||.|.|.:.|...
Mouse    66 LLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 130

  Fly   149 IVHRDLKPENILLD---ENHNVKITDFGFAKQLQEGEKLT--NLCGTPGYLAPETLKCNMFEGSP 208
            :|||||||||:||.   :...||:.|||.|.:: |||:..  ...||||||:||.|:      ..
Mouse   131 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEV-EGEQQAWFGFAGTPGYLSPEVLR------KD 188

  Fly   209 GYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLV 273
            .|.:.||:||||||::.||||.||||...|..:.:.|..|.|.|.||||..::.:.||||.|.|.
Mouse   189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 253

  Fly   274 VDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPI-APAQTNSRHLLQPEASSYRFGQLNSSCAGA 337
            ::||:|||..|.|:||:.:....:....|....: ...:.|:|..|:        |.:.::....
Mouse   254 INPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK--------GAILTTMLAT 310

  Fly   338 PNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTT 388
            .|:    .......|:..||......:|:...         ..:|.:||||
Mouse   311 RNF----SGGKSGGNKKNDGVKKRKSSSSVQL---------MESSESTNTT 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	113/276 (41%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	112/272 (41%)
Camk2a	XP_006525604.1	STKc_CaMKII	11..302	CDD:270988	116/313 (37%)
Camk2a	XP_006525604.1	CaMKII_AD	357..484	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920