DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and Mylk

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_647461.3	Gene:	Mylk / 107589	MGIID:	894806	Length:	1950	Species:	Mus musculus

Alignment Length:	386	Identity:	120/386 - (31%)
Similarity:	174/386 - (45%)	Gaps:	49/386 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGH 87
            |:.:|.||.|....|.|.:||:|||.:|.|.....:..|.         :..||||||: ..:.|
Mouse  1495 YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAKEK---------DNIRQEISIM-NCLHH 1549

  Fly    88 PYIIDLQDVFESDAFVFLVFELCPKGELFD-YLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVH 151
            |.::...|.||..|.:.:|.|:...||||: .:.....|:|::....||||.|||||||.:.|||
Mouse  1550 PKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVH 1614

  Fly   152 RDLKPENILL--DENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKCNMFEGSPGYSQEV 214
            .|||||||:.  .....:|:.|||.|::|:....|..|.|||.::|||.:.....    ||:  .
Mouse  1615 LDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPI----GYA--T 1673

  Fly   215 DIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQR 279
            |:|:.|||.:.|:.|..||........|.|:....:.|....:.:||:|.||.|...|..|...|
Mouse  1674 DMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNR 1738

  Fly   280 ITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPEASSY---RFGQLNSSCAGAPNYL 341
            :...:.|:||:     ||.|.::         ..::.|.:.....|   |..|...:...|...|
Mouse  1739 LDCTQCLQHPW-----LMKDTKN---------MEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRL 1789

  Fly   342 YCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTTANTSNSALASASSH 402
                    ||..|..| |....:|..|.|    ||.||....:.:..:.....|:|....|
Mouse  1790 --------SSMAMISG-LSGRKSSTGSPT----SPINAEKLESEDDVSQAFLEAVAEEKPH 1837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	96/270 (36%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	96/270 (36%)
Mylk	NP_647461.3	I-set	42..132	CDD:254352
		Ig	42..131	CDD:299845
		I-set	165..254	CDD:254352
		Ig	183..251	CDD:143165
		23ISL	255..409	CDD:293226
		I-set	411..501	CDD:254352
		Ig	428..498	CDD:143165
		I-set	511..597	CDD:254352
		IGc2	524..587	CDD:197706
		I-set	620..709	CDD:254352
		Ig	637..706	CDD:143165
		I-set	718..806	CDD:254352
		Ig	721..806	CDD:299845
		I-set	1129..1218	CDD:254352
		IGc2	1142..1208	CDD:197706
		Ig	1269..1366	CDD:299845
		I-set	1269..1358	CDD:254352
		FN3	1362..1453	CDD:238020
		STKc_MLCK1	1492..1750	CDD:271093	96/275 (35%)
		Pkinase	1495..1750	CDD:278497	96/275 (35%)
		I-set	1840..1930	CDD:254352
		IGc2	1853..1920	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010