DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PhKgamma and camk2a

DIOPT Version :9

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_012813848.1	Gene:	camk2a / 100101771	XenbaseID:	XB-GENE-868353	Length:	516	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	134/395 - (33%)
Similarity:	202/395 - (51%)	Gaps:	45/395 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQ 83
            |..:|:..|.||:|..|.||||::..:|:|:|||||:    |:......:..||   :|..|.|
Frog     9 FSEEYQLFEELGKGAFSIVRRCVKVLSGQEYAAKIIN----TKKLSARDHQKLE---REARICR- 65

  Fly    84 VMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKS 148
            ::.||.|:.|.|....:...:|||:|...||||:.:.:....||......::||.|.|.:.|...
Frog    66 LLKHPNIVRLHDSISEEGHHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 130

  Fly   149 IVHRDLKPENILLD---ENHNVKITDFGFAKQLQEGEKLT--NLCGTPGYLAPETLKCNMFEGSP 208
            :|||||||||:||.   :...||:.|||.|.:: |||:..  ...||||||:||.|:      ..
Frog   131 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEV-EGEQQAWFGFAGTPGYLSPEVLR------KD 188

  Fly   209 GYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLV 273
            .|.:.||:||||||::.||||.||||...|..:.:.|..|.|.|.||||..::.:.||||.|.|.
Frog   189 PYGKAVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 253

  Fly   274 VDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPI-APAQTNSRHLLQPEASSYRFGQLNSSCAGA 337
            ::||:|||..|.|:||:.:....:....|....: ...:.|:|..|:        |.:.::....
Frog   254 INPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK--------GAILTTMLAT 310

  Fly   338 PNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTT---ANTSNSALASA 399
            .|:    ......||:..||......:|:...         ..:|.:||||   .:|.:.:||:.
Frog   311 RNF----SGGKSGSNKKNDGVKKRKSSSSVQL---------MESSESTNTTIEDEDTKDFSLAAQ 362

  Fly   400 SSHKT 404
            :.:.|
Frog   363 NENIT 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	114/276 (41%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	113/272 (42%)
camk2a	XP_012813848.1	STKc_CaMKII	11..302	CDD:270988	117/313 (37%)
camk2a	XP_012813848.1	CaMKII_AD	384..511	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920