DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bif and maco1a

DIOPT Version :9

Sequence 1:	NP_001259457.1	Gene:	bif / 32119	FlyBaseID:	FBgn0014133	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_956613.2	Gene:	maco1a / 393289	ZFINID:	ZDB-GENE-040426-1097	Length:	664	Species:	Danio rerio

Alignment Length:	635	Identity:	115/635 - (18%)
Similarity:	201/635 - (31%)	Gaps:	189/635 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 CKPGQSVAEGKPSAK-----ETIVDNSKSCSKTKSISDKLQSNKFIIQQQQQ---QQQQQQQQQQ 281
            |:|..:...|.|...     ::.|.......|.|.:.   :.|:|.:|..||   .:||..|:|:
Zfish   151 CRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQ---KENEFYMQLLQQALPPEQQMLQRQE 212

  Fly   282 LSPTKVTVKPTMVAMQEMKKTTKQNGQHRHLAGKIGSVAGGDVDPQHPPTNPIPDSLDTGEDLSY 346
                :.|.:.|...|.|                                    .||:...::
Zfish   213 ----RETEEATSKGMSE------------------------------------ADSVLVAQN--- 234

  Fly   347 GPGIVSKLRCRYLSLALRESRQQSSKQRLQRSTSL---NTLLDRDDDEVEVEEPEMTNSQVRAKS 408
            |..|..||......|..:|..:.|:|.:.|:..|:   |.:|...|  .::::.|...:.:.||.
Zfish   235 GTAINKKLPISLPELEYKEKGKDSAKDKKQQQHSIGINNNILQTVD--AKLQDIEYMENHLNAKR 297

  Fly   409 TPPPILGAKPTPKPSSQHQRPVSLGANGAGSAVNPPSNSDQAQTGAVANGGAGSGQRSRHFKRGN 473
            ....:.|:........:      :|| |.|||.:....:...::....||...|...:|..|:..
Zfish   298 LNNELGGSAENLFLKEE------VGA-GGGSAPSKHYKNSSPRSHNSTNGSVPSSSSNRSDKKQK 355

  Fly   474 EVMKRARSVEALLCEKSPWNSQRISTAGAAAAAAPSPPAPKATAAAP--------SPVTSPTCV- 529
            ...|.......|:....|.|  ::|...|...........||...|.        |.::|.:..
Zfish   356 CTGKNLAPHRDLMENCIPNN--QLSKPDALVRLEQDIKKLKADLQASRQVEQDLRSQISSLSSAE 418

  Fly   530 ---------------TIEDKIHNARERLHSGTDTAPPKRLTSIIDDTERPPPDLVKQTLKMFE-- 577
                           .:::|:|||.:.....                        |||:...|
Zfish   419 RSMRSELGQLRQENELLQNKLHNAVQAKQKD------------------------KQTIVQLEKR 459

  Fly   578 ASANRRPRAAHRSNGVGGVASKVANYKSIIKDQKQPSSAAATPPPTGMGFASSTPLRHVHPDIIP 642
            ..|.:..|||        |..::|..|   |.:|...:.||      ...|.:...|....|.:.
Zfish   460 LKAEQEARAA--------VEKQLAEEK---KRKKMEEATAA------RAVALAAASRGECTDSLK 507

  Fly   643 RQVDSPVSALSVMMRRMELQEPETPERETRDAEATPQSEALSETERNDRDEGDGEV--------- 698
            .::....|....:...|:|:|.:..|.|.:       ::.|.:.:.|::|.   ||
Zfish   508 SRIRELESECKKLTHDMKLKEEQIRELELK-------AQELHKYKENEKDT---EVLMSALSAMQ 562

  Fly   699 DDDNHNNNDDDHDDGDDGSDNNEQRDKMGAAAAGDKPKPPAESAAGGAQRSFAASTENAHVASGS 763
            |...|..|          |.:.|.|.|:...           ||.|.|:|..       .:|.|.
Zfish   563 DKTQHLEN----------SLSAETRIKLDLF-----------SALGDAKRQL-------EIAQGQ 599

  Fly   764 SSSTSASVRKLSNN-------NDSSSGPAVTKQIGVIRPLFNSQGAGSTP 806
            .......:::|...       ..|.:..|.|..:..:.|.::|:...::|
Zfish   600 ILQKEQEIKELKQKIAEVMAVMPSITYSAETNNMTPVTPHYSSKFMDTSP 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bif	NP_001259457.1	None
maco1a	NP_956613.2	Macoilin	2..662	CDD:286769	115/635 (18%)
		DUF4118	31..114	CDD:290228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..225		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..364		12/49 (24%)
		TolA_bind_tri	386..462	CDD:292947	13/99 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..664		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13289
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030